PhD proposal (from 2019)

Rédiger le 21 May 2019 à 12:31 pm par , publié dans Actuality.

Analysis of the molecular mechanisms involved in a cytoplasmic purge of enterocytes As the intestine represents a wide surface of exchange for nutrient uptake, it constantly faces challenges from the environment, and thus needs to efficiently deal with exposure to noxious chemical and biological agents that may contaminate the ingested food. We have recently discovered that… Read more »

A mechanism for detecting microbial virulence in Drosophila

Rédiger le 16 February 2018 à 2:41 pm par , publié dans Actuality.

Researchers at the Insect Models of Innate Immunity Laboratory (CNRS) have demonstrated an original mechanism for recognizing infections in the Drosophila model organism. It allows detection of the activity of microbial enzymes responsible for virulence, rather than specific molecular patterns found in microorganisms, which constitute “non-self” signals. These results were published on February 15, 2018… Read more »

Global Experts Recruitment Chinese Program

Rédiger le 15 February 2018 à 5:49 pm par , publié dans Actuality.

Dominique FERRANDON was elected as member of the Global Experts Recruitment Chinese Program     In September 2017, Dominique FERRANDON was elected as member of the Global Experts Recruitment Chinese Program (known as “Thousand Talents”). Created in late 2008, this program aims to attract internationally recognized foreign talent to China. The 1000 Talent Program builds… Read more »

Communication: Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack

Rédiger le 24 November 2016 à 6:13 pm par , publié dans Actuality.

Besides digesting nutrients, the gut protects the host against invasion by pathogens. Enterocytes may be subjected to damage by both microbial and host defensive responses, causing their death. Here, we report a rapid epithelial response that alleviates infection stress and protects the enterocytes from the action of microbial virulence factors. Intestinal epithelia exposed to hemolysin, a… Read more »