Group leader: Dominique FERRANDON
Deciphering the molecular pathways involved in host-pathogen interactions
We aim to decipher the molecular mechanisms allowing a host and a pathogen to adapt each other:
– the host attacking the pathogen (resistance) or defending and repairing itself (resilience)
– the pathogen hijacking the host defences or simply hiding itself, and sometimes attacking the host.
We work from both the host side (drosophila) and the pathogen side (bacteria and fungi).
We are mainly focused on the epithelial barrier of the intestine, in infection models using Gram-negative bacteria (Serratia marcescens and Pseudomonas aeruginosa). We also study systemic effects with a parasitic infection model (the microsporidium Tubulinosema ratisbonensis).
The Ferrandon group
We are a very motivated small group, working all together in a helpful and enthusiastic atmosphere.
Lee et al., Cell Host & Microbe 2016
Limmer et al., PNAS 2011
Cronin et al., Science 2009
Gottar et al., Cell 2006