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2014

Journal Articles

51.

Majzoub, Karim; Hafirassou, Mohamed Lamine ; Meignin, Carine ; Goto, Akira ; Marzi, Stefano ; Fedorova, Antonina ; Verdier, Yann ; Vinh, Joëlle ; Hoffmann, Jules A; Martin, Franck ; Baumert, Thomas F; Schuster, Catherine ; Imler, Jean-Luc

RACK1 controls IRES-mediated translation of viruses Journal Article

Cell, 159 (5), pp. 1086–1095, 2014, ISSN: 1097-4172.

Abstract | Links | BibTeX | Tags: Cell Line, Cell Surface, Cytoplasmic and Nuclear, Dicistroviridae, GTP-Binding Proteins, Hepacivirus, Hepatocytes, Humans, Insect Viruses, Models, Molecular, Neoplasm Proteins, Peptide Initiation Factors, Protein Biosynthesis, Receptors, Regulatory Sequences, Ribonucleic Acid, Tumor, Virus Replication

2013

Journal Articles

50.

Quintin, Jessica; Asmar, Joelle; Matskevich, Alexey A; Lafarge, Marie-Céline; Ferrandon, Dominique

The Drosophila Toll pathway controls but does not clear Candida glabrata infections Journal Article

J. Immunol., 190 (6), pp. 2818–2827, 2013, ISSN: 1550-6606.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Animal, Antigens, Candida glabrata, Candidiasis, Cells, Cultured, Differentiation, Disease Models, Immunologic, Phagocytosis, Receptors, Signal Transducing, Signal Transduction, Toll-Like Receptors, Virulence

49.

Ayyaz, Arshad; Giammarinaro, Philippe; Liégeois, Samuel; Lestradet, Matthieu; Ferrandon, Dominique

A negative role for MyD88 in the resistance to starvation as revealed in an intestinal infection of Drosophila melanogaster with the Gram-positive bacterium Staphylococcus xylosus Journal Article

Immunobiology, 218 (4), pp. 635–644, 2013, ISSN: 1878-3279.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Animal, Antigens, Differentiation, Disease Models, Immunity, Immunologic, Innate, Intestinal Diseases, Mucosal, Mutation, Receptors, Signal Transducing, Staphylococcal Infections, Staphylococcus, Starvation, Toll-Like Receptors

2012

Journal Articles

48.

Deleury, Emeline; Dubreuil, Géraldine; Elangovan, Namasivayam; Wajnberg, Eric; Reichhart, Jean-Marc; Gourbal, Benjamin; Duval, David; Baron, Olga Lucia; Gouzy, Jérôme; Coustau, Christine

Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study Journal Article

PLoS ONE, 7 (3), pp. e32512, 2012, ISSN: 1932-6203.

Abstract | Links | BibTeX | Tags: Biomphalaria, Calmodulin, Cluster Analysis, Complementary, DNA, Expressed Sequence Tags, Ferritins, Gene Expression Profiling, Gene Expression Regulation, High-Throughput Nucleotide Sequencing, Immunity, Innate, Messenger, Pattern Recognition, Phylogeny, Receptors, RNA, Signal Transduction, Zinc Fingers

2011

Journal Articles

47.

Nehme, Nadine T; Quintin, Jessica; Cho, Ju Hyun; Lee, Janice; Lafarge, Marie-Céline; Kocks, Christine; Ferrandon, Dominique

Relative roles of the cellular and humoral responses in the Drosophila host defense against three gram-positive bacterial infections Journal Article

PLoS ONE, 6 (3), pp. e14743, 2011, ISSN: 1932-6203.

Abstract | Links | BibTeX | Tags: Antimicrobial Cationic Peptides, Carrier Proteins, Cell Surface, Cellular, Enterococcus faecalis, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Host-Pathogen Interactions, Humoral, Immunity, Innate, Micrococcus luteus, Opsonin Proteins, Phagocytosis, Receptors, Signal Transduction, Solubility, Staphylococcus aureus

2008

Journal Articles

46.

Chamy, Laure El; Leclerc, Vincent; Caldelari, Isabelle; Reichhart, Jean-Marc

Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll Journal Article

Nat. Immunol., 9 (10), pp. 1165–1170, 2008, ISSN: 1529-2916.

Abstract | Links | BibTeX | Tags: Fungi, Genetically Modified, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, In Situ Hybridization, Mycoses, Pattern Recognition, Peptide Hydrolases, Receptors, Serine Endopeptidases, Signal Transduction, Toll-Like Receptors

2006

Journal Articles

45.

Chen, Li-Ying; Wang, Juinn-Chin; Hyvert, Yann; Lin, Hui-Ping; Perrimon, Norbert; Imler, Jean-Luc; Hsu, Jui-Chou

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo Journal Article

Current biology: CB, 16 (12), pp. 1183–1193, 2006, ISSN: 0960-9822.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Antigens, Biological, Body Patterning, Cell Membrane, Differentiation, Dimerization, DNA-Binding Proteins, Embryo, Epistasis, Genetic, Immunity, Immunologic, Innate, Models, Mutation, Nonmammalian, Phenotype, Phosphoproteins, Receptors, Signal Transducing, Toll-Like Receptors, Transcription Factors, Zinc Fingers

2005

Journal Articles

44.

Kocks, Christine; Cho, Ju Hyun ; Nehme, Nadine ; Ulvila, Johanna ; Pearson, Alan M; Meister, Marie ; Strom, Charles ; Conto, Stephanie L; Hetru, Charles ; Stuart, Lynda M; Stehle, Thilo ; Hoffmann, Jules A; Reichhart, Jean-Marc ; Ferrandon, Dominique ; Rämet, Mika ; Ezekowitz, Alan R B

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila Journal Article

Cell, 123 (2), pp. 335–346, 2005, ISSN: 0092-8674.

Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid Motifs, Bacterial Infections, Cell Surface, Embryo, Escherichia coli, Flow Cytometry, Frameshift Mutation, Genes, Histidine, In Situ Hybridization, Insect, Insect Proteins, Macrophages, Membrane Proteins, Messenger, Nonmammalian, Open Reading Frames, Phagocytosis, Receptors, RNA, RNA Interference, Sequence Homology, Serratia marcescens

43.

Martinelli, Cosimo; Reichhart, Jean-Marc

Evolution and integration of innate immune systems from fruit flies to man: lessons and questions Journal Article

J. Endotoxin Res., 11 (4), pp. 243–248, 2005, ISSN: 0968-0519.

Abstract | Links | BibTeX | Tags: Biological Evolution, Cell Surface, Forecasting, Humans, Immunity, Immunological, Innate, Membrane Glycoproteins, Models, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

42.

Weber, Alexander N R; Moncrieffe, Martin C; Gangloff, Monique; Imler, Jean-Luc; Gay, Nicholas J

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway Journal Article

The Journal of Biological Chemistry, 280 (24), pp. 22793–22799, 2005, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Amino Acid, Biophysical Phenomena, Biophysics, Body Patterning, Calorimetry, Cell Line, Cell Surface, Cross-Linking Reagents, Cytokines, Dimerization, Electrophoresis, Humans, Ligands, Luciferases, Membrane Glycoproteins, Polyacrylamide Gel, Protein Binding, Protein Structure, Receptors, Recombinant Proteins, Sequence Homology, Signal Transduction, Tertiary, Time Factors, Toll-Like Receptors, Ultracentrifugation

2004

Journal Articles

41.

Bischoff, Vincent; Vignal, Cécile; Boneca, Ivo G; Michel, Tatiana; Hoffmann, Jules A; Royet, Julien

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria Journal Article

Nat. Immunol., 5 (11), pp. 1175–1180, 2004, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Carrier Proteins, Cell Surface, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Mutation, Mycoses, Receptors, Staphylococcus aureus, Toll-Like Receptors

40.

Leclerc, Vincent; Reichhart, Jean-Marc

The immune response of Drosophila melanogaster Journal Article

Immunol. Rev., 198 , pp. 59–71, 2004, ISSN: 0105-2896.

Abstract | BibTeX | Tags: Cell Surface, Immunity, Immunological, Innate, Models, Receptors, Signal Transduction, Toll-Like Receptors

39.

Ferrandon, Dominique; Imler, Jean-Luc; Hoffmann, Jules A

Sensing infection in Drosophila: Toll and beyond Journal Article

Semin Immunol, 16 , pp. 43–53, 2004, ISSN: 1044-5323.

Abstract | BibTeX | Tags: Carrier Proteins/chemistry/immunology/physiology, Cell Surface/immunology/*physiology, Drosophila Proteins/chemistry/immunology/*physiology, Drosophila/genetics/*immunology/microbiology, Fungi/immunology, Gene Expression Regulation, Gram-Negative Bacterial Infections/immunology, Gram-Positive Bacterial Infections/immunology, Immunological, Insect Proteins/chemistry/immunology/physiology, Models, Non-U.S. Gov't, Receptors, Signal Transduction/immunology/physiology, Support

38.

Imler, Jean-Luc; Zheng, Liangbiao

Biology of Toll receptors: lessons from insects and mammals Journal Article

Journal of Leukocyte Biology, 75 (1), pp. 18–26, 2004, ISSN: 0741-5400.

Abstract | Links | BibTeX | Tags: Anopheles, Cell Surface, Humans, Membrane Glycoproteins, Mice, Phylogeny, Plant Physiological Phenomena, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

37.

Imler, Jean-Luc; Ferrandon, Dominique ; Royet, Julien ; Reichhart, Jean-Marc ; Hetru, Charles ; Hoffmann, Jules A

Toll-dependent and Toll-independent immune responses in Drosophila Journal Article

Journal of Endotoxin Research, 10 (4), pp. 241–246, 2004, ISSN: 0968-0519.

Abstract | Links | BibTeX | Tags: Acute-Phase Proteins, Blood Proteins, Cell Surface, Insect Proteins, Membrane Glycoproteins, Receptors, Toll-Like Receptor 5, Toll-Like Receptors, Up-Regulation

2003

Journal Articles

36.

Gobert, Vanessa; Gottar, Marie; Matskevich, Alexey A; Rutschmann, Sophie; Royet, Julien; Belvin, Marcia; Hoffmann, Jules A; Ferrandon, Dominique

Dual activation of the Drosophila toll pathway by two pattern recognition receptors Journal Article

Science, 302 (5653), pp. 2126–2130, 2003, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Carrier Proteins, Cell Surface, DNA Transposable Elements, Gene Expression, Genes, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Hypocreales, Insect, Insect Proteins, Mutation, Phenotype, Receptors, Serine Endopeptidases, Toll-Like Receptors

35.

Ligoxygakis, Petros; Roth, Siegfried; Reichhart, Jean-Marc

A serpin regulates dorsal-ventral axis formation in the Drosophila embryo Journal Article

Curr. Biol., 13 (23), pp. 2097–2102, 2003, ISSN: 0960-9822.

Abstract | BibTeX | Tags: Body Patterning, Cell Surface, Crosses, Female, Genetic, Immunohistochemistry, Microinjections, Receptors, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors

34.

Reichhart, Jean-Marc

TLR5 takes aim at bacterial propeller Journal Article

Nat. Immunol., 4 (12), pp. 1159–1160, 2003, ISSN: 1529-2908.

Links | BibTeX | Tags: Bacterial Physiological Phenomena, Cell Surface, Flagella, Flagellin, Humans, Membrane Glycoproteins, Receptors, Toll-Like Receptor 5, Toll-Like Receptors

33.

Royet, Julien; Reichhart, Jean-Marc

Detection of peptidoglycans by NOD proteins Journal Article

Trends Cell Biol., 13 (12), pp. 610–614, 2003, ISSN: 0962-8924.

Abstract | BibTeX | Tags: Adaptor Proteins, Apoptosis, Carrier Proteins, Gram-Positive Bacteria, Humans, Immunity, Immunologic, Innate, Nod1 Signaling Adaptor Protein, Oligopeptides, Peptidoglycan, Receptors, Signal Transducing, Signal Transduction

32.

Hoffmann, Jules A

The immune response of Drosophila Journal Article

Nature, 426 (6962), pp. 33–38, 2003, ISSN: 1476-4687.

Abstract | Links | BibTeX | Tags: Cell Surface, Immunity, Innate, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

31.

Goto, Akira; Blandin, Stéphanie A; Royet, Julien; Reichhart, Jean-Marc; Levashina, Elena A

Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies Journal Article

Nucleic Acids Res., 31 (22), pp. 6619–6623, 2003, ISSN: 1362-4962.

Abstract | BibTeX | Tags: Cell Surface, Double-Stranded, Epistasis, Female, Genetic, Green Fluorescent Proteins, Homeodomain Proteins, Luminescent Proteins, Phenotype, Receptors, RNA, RNA Interference, Serpins, Signal Transduction, Time Factors, Toll-Like Receptors, Transcription Factors

30.

Weber, Alexander N R; Tauszig-Delamasure, Servane ; Hoffmann, Jules A; Lelièvre, Eric ; Gascan, Hugues ; Ray, Keith P; Morse, Mary A; Imler, Jean-Luc ; Gay, Nicholas J

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling Journal Article

Nature Immunology, 4 (8), pp. 794–800, 2003, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Cell Surface, Insect Proteins, Protein Binding, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

29.

Bilak, Hana; Tauszig-Delamasure, S; Imler, Jean-Luc

Toll and Toll-like receptors in Drosophila Journal Article

Biochemical Society Transactions, 31 (Pt 3), pp. 648–651, 2003, ISSN: 0300-5127.

Abstract | Links | BibTeX | Tags: Biological Evolution, Cell Surface, Fungi, Genome, Gram-Negative Bacteria, Gram-Positive Bacteria, Membrane Glycoproteins, Receptors, Toll-Like Receptor 5, Toll-Like Receptors

28.

Imler, Jean-Luc; Hoffmann, Jules A

Toll signaling: the TIReless quest for specificity Journal Article

Nature Immunology, 4 (2), pp. 105–106, 2003, ISSN: 1529-2908.

Links | BibTeX | Tags: Cell Surface, Dendritic Cells, Humans, Immunological, Interferon-beta, Membrane Glycoproteins, Mice, Models, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

27.

Luna, C; Hoa, N T; Zhang, J; Kanzok, S M; Brown, S E; Imler, Jean-Luc; Knudson, D L; Zheng, L

Characterization of three Toll-like genes from mosquito Aedes aegypti Journal Article

Insect Molecular Biology, 12 (1), pp. 67–74, 2003, ISSN: 0962-1075.

Abstract | BibTeX | Tags: Aedes, Base Sequence, Cell Surface, Chimera, Cloning, Developmental, Female, Gene Expression Regulation, Genetic, Insect Proteins, Male, Messenger, Models, Molecular, Mutagenesis, Promoter Regions, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sequence Alignment, Signal Transduction, Site-Directed, Transfection

26.

Kambris, Zakaria; Bilak, Hana; D'Alessandro, Rosalba; Belvin, Marcia; Imler, Jean-Luc; Capovilla, Maria

DmMyD88 controls dorsoventral patterning of the Drosophila embryo Journal Article

EMBO reports, 4 (1), pp. 64–69, 2003, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Alleles, Antigens, Base Sequence, Cell Surface, Complementary, Developmental, Differentiation, DNA, DNA Transposable Elements, Egg Proteins, Embryo, Exons, Female, Gene Expression Regulation, Genetically Modified, Genotype, Immunity, Immunologic, Innate, Insertional, Male, Messenger, Morphogenesis, Mutagenesis, Myeloid Differentiation Factor 88, Nonmammalian, Oocytes, Protein Biosynthesis, Protein Structure, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transducing, Tertiary, Toll-Like Receptors, Zygote

2002

Journal Articles

25.

Munier, Anne-Isabelle; Doucet, Daniel; Perrodou, Emmanuel; Zachary, Daniel; Meister, Marie; Hoffmann, Jules A; Janeway, Charles A; Lagueux, Marie

PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae Journal Article

EMBO Rep., 3 (12), pp. 1195–1200, 2002, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Antibodies, Blotting, Cell Differentiation, Hemocytes, Immunohistochemistry, Larva, Ligands, Platelet-Derived Growth Factor, Receptors, Vascular Endothelial Growth Factor, Western

24.

Ligoxygakis, Petros; Pelte, Nadège ; Ji, Chuanyi ; Leclerc, Vincent ; Duvic, Bernard ; Belvin, Marcia ; Jiang, Haobo ; Hoffmann, Jules A; Reichhart, Jean-Marc

A serpin mutant links Toll activation to melanization in the host defence of Drosophila Journal Article

EMBO J., 21 (23), pp. 6330–6337, 2002, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Cell Surface, Hemolymph, Infection, Melanins, Receptors, Serpins, Toll-Like Receptors

23.

Kambris, Zakaria; Hoffmann, Jules A; Imler, Jean-Luc ; Capovilla, Maria

Tissue and stage-specific expression of the Tolls in Drosophila embryos Journal Article

Gene expression patterns: GEP, 2 (3-4), pp. 311–317, 2002, ISSN: 1567-133X.

Abstract | BibTeX | Tags: Blotting, Cell Surface, Gene Expression Profiling, Larva, Multigene Family, Northern, Receptors, Toll-Like Receptors

22.

Duvic, Bernard; Hoffmann, Jules A; Meister, Marie; Royet, Julien

Notch signaling controls lineage specification during Drosophila larval hematopoiesis Journal Article

Curr. Biol., 12 (22), pp. 1923–1927, 2002, ISSN: 0960-9822.

Abstract | BibTeX | Tags: Cell Differentiation, Hematopoiesis, Larva, Lymphoid Tissue, Membrane Proteins, Notch, Receptors, Signal Transduction

21.

Ligoxygakis, Petros; Pelte, Nadège ; Hoffmann, Jules A; Reichhart, Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Journal Article

Science, 297 (5578), pp. 114–116, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, Hypocreales, Insect, Insect Proteins, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, Serine Endopeptidases, Tertiary, Toll-Like Receptors

20.

Hoffmann, Jules A; Reichhart, Jean-Marc

Drosophila innate immunity: an evolutionary perspective Journal Article

Nat. Immunol., 3 (2), pp. 121–126, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Biological Evolution, Cell Surface, Immunity, Immunological, Innate, Membrane Glycoproteins, Models, Receptors, Signal Transduction, Toll-Like Receptors

19.

Ligoxygakis, Petros; Bulet, Philippe; Reichhart, Jean-Marc

Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila Journal Article

EMBO Rep., 3 (7), pp. 666–673, 2002, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Cell Adhesion Molecules, Fat Body, Gene Expression Regulation, Genes, Immunohistochemistry, Immunologic, Insect, Insect Proteins, Larva, Mass, Matrix-Assisted Laser Desorption-Ionization, Membrane Proteins, Receptors, Reporter, Spectrometry, Transgenes

18.

Tauszig-Delamasure, Servane; Bilak, Hana ; Capovilla, Maria ; Hoffmann, Jules A; Imler, Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

Nature Immunology, 3 (1), pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, Hypocreales, Immunologic, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

17.

Imler, Jean-Luc; Hoffmann, Jules A

Toll receptors in Drosophila: a family of molecules regulating development and immunity Journal Article

Current Topics in Microbiology and Immunology, 270 , pp. 63–79, 2002, ISSN: 0070-217X.

Abstract | BibTeX | Tags: Cell Surface, Genetic, Gram-Negative Bacteria, Receptors, Signal Transduction, Toll-Like Receptors, Transcription

2001

Journal Articles

16.

Michel, T; Reichhart, Jean-Marc ; Hoffmann, Jules A; Royet, Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Journal Article

Nature, 414 (6865), pp. 756–759, 2001, ISSN: 0028-0836.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, Humans, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, Sequence Homology, Toll-Like Receptors

15.

Imler, Jean-Luc; Hoffmann, Jules A

Toll receptors in innate immunity Journal Article

Trends in Cell Biology, 11 (7), pp. 304–311, 2001, ISSN: 0962-8924.

Abstract | BibTeX | Tags: Cell Surface, Humans, Immunity, Immunologic, Innate, Membrane Glycoproteins, Membrane Proteins, Receptors, Toll-Like Receptors

2000

Journal Articles

14.

Lagueux, Marie; Perrodou, E; Levashina, Elena A; Capovilla, Maria; Hoffmann, Jules A

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila Journal Article

Proc. Natl. Acad. Sci. U.S.A., 97 (21), pp. 11427–11432, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: alpha-Macroglobulins, Amino Acid, Cell Surface, Complement C3, Esters, Genetic, Insect Proteins, Janus Kinases, Membrane Glycoproteins, Mutation, Protein-Tyrosine Kinases, Proteins, Receptors, Sequence Homology, Sulfhydryl Compounds, Toll-Like Receptors, Transcription, Transcription Factors

13.

Rutschmann, Sophie; Jung, Alain C; Zhou, R; Silverman, N; Hoffmann, Jules A; Ferrandon, Dominique

Role of Drosophila IKK gamma in a toll-independent antibacterial immune response Journal Article

Nat. Immunol., 1 (4), pp. 342–347, 2000, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Antigens, Bacterial, Cell Surface, Gene Expression Regulation, I-kappa B Kinase, Immunity, Innate, Insect Proteins, Membrane Glycoproteins, Protein-Serine-Threonine Kinases, Receptors, Signal Transduction, Toll-Like Receptors, Transcription Factors

12.

Tauszig, Servane; Jouanguy, Emmanuelle ; Hoffmann, Jules A; Imler, Jean-Luc

Toll-related receptors and the control of antimicrobial peptide expression in Drosophila Journal Article

Proceedings of the National Academy of Sciences of the United States of America, 97 (19), pp. 10520–10525, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Blotting, Cell Line, Cell Surface, Membrane Glycoproteins, Multigene Family, Northern, Peptides, Receptors, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptors

11.

Imler, Jean-Luc; Hoffmann, Jules A

Signaling mechanisms in the antimicrobial host defense of Drosophila Journal Article

Current Opinion in Microbiology, 3 (1), pp. 16–22, 2000, ISSN: 1369-5274.

Abstract | BibTeX | Tags: Anti-Infective Agents, Cell Surface, Gene Expression Regulation, Genes, Insect, Insect Proteins, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptors

10.

Imler, Jean-Luc; Hoffmann, Jules A

Toll and Toll-like proteins: an ancient family of receptors signaling infection Journal Article

Reviews in Immunogenetics, 2 (3), pp. 294–304, 2000, ISSN: 1398-1714.

Abstract | BibTeX | Tags: Adaptor Proteins, Antigens, Autoantigens, CD14, Cell Adhesion Molecules, Cell Surface, Differentiation, DNA-Binding Proteins, Gene Expression Regulation, I-kappa B Proteins, Immunity, Immunologic, Infection, Innate, Insect Proteins, Interleukin-1 Receptor-Associated Kinases, Knockout, Larva, Lipopolysaccharides, Mammals, MAP Kinase Signaling System, Membrane Glycoproteins, Membrane Proteins, Mice, Multigene Family, Myeloid Differentiation Factor 88, NF-kappa B, Peptidoglycan, Phosphorylation, Post-Translational, Protein Kinases, Protein Processing, Protein Structure, Receptors, Recombinant Fusion Proteins, Signal Transducing, Signal Transduction, Teichoic Acids, Tertiary, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptor 6, Toll-Like Receptor 9, Toll-Like Receptors, Ubiquitins

9.

Imler, Jean-Luc; Tauszig, Servane ; Jouanguy, Emmanuelle ; Forestier, C; Hoffmann, Jules A

LPS-induced immune response in Drosophila Journal Article

Journal of Endotoxin Research, 6 (6), pp. 459–462, 2000, ISSN: 0968-0519.

Abstract | BibTeX | Tags: Biological, Cell Line, Cell Surface, Defensins, Genes, Genetic, Insect, Insect Proteins, Lipopolysaccharides, Membrane Glycoproteins, Models, Mutation, Promoter Regions, Receptors, Signal Transduction, Toll-Like Receptors

1999

Journal Articles

8.

Levashina, Elena A; Langley, E; Green, C; Gubb, David ; Ashburner, M; Hoffmann, Jules A; Reichhart, Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Journal Article

Science, 285 (5435), pp. 1917–1919, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

7.

Manfruelli, P; Reichhart, Jean-Marc ; Steward, R; Hoffmann, Jules A; Lemaitre, Bruno

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF Journal Article

EMBO J., 18 (12), pp. 3380–3391, 1999, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Cell Surface, Clone Cells, DNA-Binding Proteins, Fat Body, Female, Gene Expression Regulation, Genes, Insect, Insect Proteins, Larva, Male, Membrane Glycoproteins, Mosaicism, Mutation, Nuclear Proteins, Phosphoproteins, Receptors, Reporter, Signal Transduction, Toll-Like Receptors, Transcription Factors

1998

Journal Articles

6.

Ferrandon, Dominique; Jung, Alain C; Criqui, M; Lemaitre, Bruno; Uttenweiler-Joseph, S; Michaut, Lydia; Reichhart, Jean-Marc; Hoffmann, Jules A

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway Journal Article

EMBO J., 17 (5), pp. 1217–1227, 1998, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Bacteria, Cell Surface, Developmental, Digestive System, Epithelium, Fat Body, Female, Fungal, Gene Expression Regulation, Genes, Green Fluorescent Proteins, Insect Proteins, Larva, Luminescent Proteins, Male, Membrane Glycoproteins, Organ Specificity, Receptors, Reporter, Respiratory System, Spores, Toll-Like Receptors, Trachea, Transgenes

5.

Nicolas, E; Reichhart, Jean-Marc ; Hoffmann, Jules A; Lemaitre, Bruno

In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila Journal Article

J. Biol. Chem., 273 (17), pp. 10463–10469, 1998, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Cell Surface, DNA-Binding Proteins, Gene Expression Regulation, Insect Proteins, Larva, Membrane Glycoproteins, Phosphoproteins, Proto-Oncogene Proteins, Receptors, Signal Transduction, Toll-Like Receptors, Transcription Factor RelB, Transcription Factors

1996

Journal Articles

4.

Hoffmann, Jules A; Reichhart, Jean-Marc ; Hetru, Charles

Innate immunity in higher insects Journal Article

Curr. Opin. Immunol., 8 (1), pp. 8–13, 1996, ISSN: 0952-7915.

Abstract | BibTeX | Tags: Base Sequence, Cyclic, Immunity, Immunologic, Immunological, Innate, Insects, Models, Peptide Hydrolases, Peptides, Receptors

3.

Lemaitre, Bruno; Nicolas, E; Michaut, Lydia ; Reichhart, Jean-Marc ; Hoffmann, Jules A

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults Journal Article

Cell, 86 (6), pp. 973–983, 1996, ISSN: 0092-8674.

Abstract | BibTeX | Tags: Antifungal Agents, Cell Surface, DNA-Binding Proteins, Fungi, Gene Expression, Genes, Insect, Insect Hormones, Insect Proteins, Membrane Glycoproteins, MHC Class II, Mutation, Mycoses, NF-kappa B, Phosphoproteins, Proteins, Receptors, Signal Transduction, Toll-Like Receptors

1995

Journal Articles

2.

Lemaitre, Bruno; Meister, Marie ; Govind, S; Georgel, Philippe ; Steward, R; Reichhart, Jean-Marc ; Hoffmann, Jules A

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila Journal Article

EMBO J., 14 (3), pp. 536–545, 1995, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Biological Transport, Cell Nucleus, Cell Surface, DNA-Binding Proteins, Fat Body, Gene Expression Regulation, Genetic, Immunity, Immunohistochemistry, Insect Hormones, Insect Proteins, Melanins, Membrane Glycoproteins, Mutation, Neoplasms, Nuclear Proteins, Phosphoproteins, Receptors, Signal Transduction, Toll-Like Receptors, Transcription, Transcription Factors

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