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2012

Journal Articles

16.

Coste, Franck; Kemp, Cordula ; Bobezeau, Vanessa ; Hetru, Charles ; Kellenberger, Christine ; Imler, Jean-Luc ; Roussel, Alain

Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster Journal Article

PloS One, 7 (3), pp. e33416, 2012, ISSN: 1932-6203.

Abstract | Links | BibTeX | Tags: Aphids, Crystallography, Janus Kinases, Protein Folding, Protein Structure, Signal Transduction, STAT Transcription Factors, Tertiary, Transcription Factors, X-Ray

2010

Journal Articles

15.

Whisstock, James C; Silverman, Gary A; Bird, Phillip I; Bottomley, Stephen P; Kaiserman, Dion; Luke, Cliff J; Pak, Stephen C; Reichhart, Jean-Marc; Huntington, James A

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions Journal Article

J. Biol. Chem., 285 (32), pp. 24307–24312, 2010, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: Biological, Biological Transport, Biophysics, Catalytic Domain, Hormones, Humans, Kinetics, Models, Peptide Hydrolases, Protein Binding, Protein Conformation, Protein Structure, Serpins, Substrate Specificity, Tertiary, Thrombin

2009

Journal Articles

14.

Mishima, Yumiko; Quintin, Jessica; Aimanianda, Vishukumar; Kellenberger, Christine; Coste, Franck; Clavaud, Cecile; Hetru, Charles; Hoffmann, Jules A; Latgé, Jean-Paul; Ferrandon, Dominique; Roussel, Alain

The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors Journal Article

J. Biol. Chem., 284 (42), pp. 28687–28697, 2009, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: beta-Glucans, Bombyx, Carrier Proteins, Crystallography, Fungal Proteins, Hemolymph, Ligands, Molecular Conformation, Mutagenesis, Polysaccharides, Protein Structure, Secondary, Tertiary, X-Ray

2007

Journal Articles

13.

Weber, Alexander N R; Gangloff, Monique; Moncrieffe, Martin C; Hyvert, Yann; Imler, Jean-Luc; Gay, Nicholas J

Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand Journal Article

The Journal of Biological Chemistry, 282 (18), pp. 13522–13531, 2007, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Cytokines, Dimerization, Ligands, Post-Translational, Protein Binding, Protein Processing, Protein Structure, Signal Transduction, Tertiary, Toll-Like Receptors

2005

Journal Articles

12.

Weber, Alexander N R; Moncrieffe, Martin C; Gangloff, Monique; Imler, Jean-Luc; Gay, Nicholas J

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway Journal Article

The Journal of Biological Chemistry, 280 (24), pp. 22793–22799, 2005, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Amino Acid, Biophysical Phenomena, Biophysics, Body Patterning, Calorimetry, Cell Line, Cell Surface, Cross-Linking Reagents, Cytokines, Dimerization, Electrophoresis, Humans, Ligands, Luciferases, Membrane Glycoproteins, Polyacrylamide Gel, Protein Binding, Protein Structure, Receptors, Recombinant Proteins, Sequence Homology, Signal Transduction, Tertiary, Time Factors, Toll-Like Receptors, Ultracentrifugation

2004

Journal Articles

11.

Blandin, Stephanie A; Shiao, Shin-Hong; Moita, Luis F; Janse, Chris J; Waters, Andrew P; Kafatos, Fotis C; Levashina, Elena A

Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae Journal Article

Cell, 116 (5), pp. 661–670, 2004, ISSN: 0092-8674.

Abstract | BibTeX | Tags: Anopheles, Female, Genetic, Humans, Insect Proteins, Insect Vectors, Malaria, Models, Molecular, Plasmodium berghei, Polymorphism, Protein Structure, RNA, Sequence Alignment, Tertiary

2003

Journal Articles

10.

Weber, Alexander N R; Tauszig-Delamasure, Servane ; Hoffmann, Jules A; Lelièvre, Eric ; Gascan, Hugues ; Ray, Keith P; Morse, Mary A; Imler, Jean-Luc ; Gay, Nicholas J

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling Journal Article

Nature Immunology, 4 (8), pp. 794–800, 2003, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Cell Surface, Insect Proteins, Protein Binding, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

9.

Imler, Jean-Luc; Hoffmann, Jules A

Toll signaling: the TIReless quest for specificity Journal Article

Nature Immunology, 4 (2), pp. 105–106, 2003, ISSN: 1529-2908.

Links | BibTeX | Tags: Cell Surface, Dendritic Cells, Humans, Immunological, Interferon-beta, Membrane Glycoproteins, Mice, Models, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

8.

Kambris, Zakaria; Bilak, Hana; D'Alessandro, Rosalba; Belvin, Marcia; Imler, Jean-Luc; Capovilla, Maria

DmMyD88 controls dorsoventral patterning of the Drosophila embryo Journal Article

EMBO reports, 4 (1), pp. 64–69, 2003, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Alleles, Antigens, Base Sequence, Cell Surface, Complementary, Developmental, Differentiation, DNA, DNA Transposable Elements, Egg Proteins, Embryo, Exons, Female, Gene Expression Regulation, Genetically Modified, Genotype, Immunity, Immunologic, Innate, Insertional, Male, Messenger, Morphogenesis, Mutagenesis, Myeloid Differentiation Factor 88, Nonmammalian, Oocytes, Protein Biosynthesis, Protein Structure, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transducing, Tertiary, Toll-Like Receptors, Zygote

2002

Journal Articles

7.

Christophides, George K; Zdobnov, Evgeny; Barillas-Mury, Carolina; Birney, Ewan; Blandin, Stephanie A; Blass, Claudia; Brey, Paul T; Collins, Frank H; Danielli, Alberto; Dimopoulos, George; Hetru, Charles; Hoa, Ngo T; Hoffmann, Jules A; Kanzok, Stefan M; Letunic, Ivica; Levashina, Elena A; Loukeris, Thanasis G; Lycett, Gareth; Meister, Stephan; Michel, Kristin; Moita, Luis F; Müller, Hans-Michael; Osta, Mike A; Paskewitz, Susan M; Reichhart, Jean-Marc; Rzhetsky, Andrey; Troxler, Laurent; Vernick, Kenneth D; Vlachou, Dina; Volz, Jennifer; von Mering, Christian; Xu, Jiannong; Zheng, Liangbiao; Bork, Peer; Kafatos, Fotis C

Immunity-related genes and gene families in Anopheles gambiae Journal Article

Science, 298 (5591), pp. 159–165, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Alternative Splicing, Anopheles, Apoptosis, Bacteria, bioinformatic, Catechol Oxidase, Computational Biology, Enzyme Precursors, Gene Expression Regulation, Genes, Genetic, Genome, Immunity, Innate, Insect, Insect Proteins, Multigene Family, Peptides, Phylogeny, Plasmodium, Protein Structure, Selection, Serine Endopeptidases, Serpins, Signal Transduction, Tertiary

6.

Ligoxygakis, Petros; Pelte, Nadège ; Hoffmann, Jules A; Reichhart, Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Journal Article

Science, 297 (5578), pp. 114–116, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, Hypocreales, Insect, Insect Proteins, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, Serine Endopeptidases, Tertiary, Toll-Like Receptors

5.

Tauszig-Delamasure, Servane; Bilak, Hana ; Capovilla, Maria ; Hoffmann, Jules A; Imler, Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

Nature Immunology, 3 (1), pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, Hypocreales, Immunologic, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

2001

Journal Articles

4.

Georgel, Philippe; Naitza, S; Kappler, Christine ; Ferrandon, Dominique ; Zachary, Daniel ; Swimmer, C; Kopczynski, C; Duyk, G; Reichhart, Jean-Marc ; Hoffmann, Jules A

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis Journal Article

Dev. Cell, 1 (4), pp. 503–514, 2001, ISSN: 1534-5807.

Abstract | BibTeX | Tags: Anti-Infective Agents, Apoptosis, Bacterial Infections, Caspases, Chromosome Mapping, Cysteine Proteinase Inhibitors, DNA Damage, Female, Gene Expression, I-kappa B Kinase, Immunocompromised Host, In Situ Nick-End Labeling, Insect Proteins, Male, Mutation, Phenotype, Protein Structure, Protein-Serine-Threonine Kinases, Tertiary

3.

Levashina, Elena A; Moita, L F; Blandin, Stéphanie A; Vriend, G; Lagueux, Marie; Kafatos, F C

Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae Journal Article

Cell, 104 (5), pp. 709–718, 2001, ISSN: 0092-8674.

Abstract | BibTeX | Tags: alpha-Macroglobulins, Anopheles, Cells, Cloning, Complement C3, Cultured, DNA Fragmentation, Double-Stranded, Female, Genetic, Gram-Negative Bacteria, Hemocytes, Insect Proteins, Molecular, Nucleic Acid Denaturation, Phagocytosis, Protein Structure, RNA, Tertiary, Transcription

2000

Journal Articles

2.

Imler, Jean-Luc; Hoffmann, Jules A

Toll and Toll-like proteins: an ancient family of receptors signaling infection Journal Article

Reviews in Immunogenetics, 2 (3), pp. 294–304, 2000, ISSN: 1398-1714.

Abstract | BibTeX | Tags: Adaptor Proteins, Antigens, Autoantigens, CD14, Cell Adhesion Molecules, Cell Surface, Differentiation, DNA-Binding Proteins, Gene Expression Regulation, I-kappa B Proteins, Immunity, Immunologic, Infection, Innate, Insect Proteins, Interleukin-1 Receptor-Associated Kinases, Knockout, Larva, Lipopolysaccharides, Mammals, MAP Kinase Signaling System, Membrane Glycoproteins, Membrane Proteins, Mice, Multigene Family, Myeloid Differentiation Factor 88, NF-kappa B, Peptidoglycan, Phosphorylation, Post-Translational, Protein Kinases, Protein Processing, Protein Structure, Receptors, Recombinant Fusion Proteins, Signal Transducing, Signal Transduction, Teichoic Acids, Tertiary, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptor 6, Toll-Like Receptor 9, Toll-Like Receptors, Ubiquitins

1998

Journal Articles

1.

Taguchi, S; Bulet, Philippe; Hoffmann, Jules A

A novel insect defensin from the ant Formica rufa Journal Article

Biochimie, 80 (4), pp. 343–346, 1998, ISSN: 0300-9084.

Abstract | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Ants, Chromatography, High Pressure Liquid, Insect Proteins, Insects, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Structure, Secondary, Sequence Alignment, Sequence Homology, Spectrometry