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2011

Journal Articles

15.

Reichhart, Jean-Marc; Gubb, David; Leclerc, Vincent

The Drosophila serpins: multiple functions in immunity and morphogenesis Journal Article

Meth. Enzymol., 499 , pp. 205–225, 2011, ISSN: 1557-7988.

Abstract | Links | BibTeX | Tags: Immunity, Innate, Morphogenesis, Serpins, Signal Transduction

2010

Journal Articles

14.

Gubb, David; Sanz-Parra, Arantza; Barcena, Laura; Troxler, Laurent; Fullaondo, Ane

Protease inhibitors and proteolytic signalling cascades in insects Journal Article

Biochimie, 92 (12), pp. 1749–1759, 2010, ISSN: 1638-6183.

Abstract | Links | BibTeX | Tags: bioinformatic, Insect Proteins, Insects, Macroglobulins, Peptide Hydrolases, Protease Inhibitors, Serpins, Signal Transduction

13.

Silverman, Gary A; Whisstock, James C; Bottomley, Stephen P; Huntington, James A; Kaiserman, Dion; Luke, Cliff J; Pak, Stephen C; Reichhart, Jean-Marc; Bird, Phillip I

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems Journal Article

J. Biol. Chem., 285 (32), pp. 24299–24305, 2010, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: Biological, Caenorhabditis elegans, Cell Death, Cell Differentiation, Cell Survival, Homeostasis, Humans, Immunity, Innate, Mice, Models, Phenotype, Serpins, Transgenes, Transgenic

12.

Whisstock, James C; Silverman, Gary A; Bird, Phillip I; Bottomley, Stephen P; Kaiserman, Dion; Luke, Cliff J; Pak, Stephen C; Reichhart, Jean-Marc; Huntington, James A

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions Journal Article

J. Biol. Chem., 285 (32), pp. 24307–24312, 2010, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: Biological, Biological Transport, Biophysics, Catalytic Domain, Hormones, Humans, Kinetics, Models, Peptide Hydrolases, Protein Binding, Protein Conformation, Protein Structure, Serpins, Substrate Specificity, Tertiary, Thrombin

11.

Matskevich, Alexey A; Quintin, Jessica; Ferrandon, Dominique

The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll-pathway activation function Journal Article

Eur. J. Immunol., 40 (5), pp. 1244–1254, 2010, ISSN: 1521-4141.

Abstract | Links | BibTeX | Tags: Agglutination, Beauveria, Beauveria/immunology, Candida albicans, Candida albicans/immunology, Carrier Proteins, Carrier Proteins/*immunology/pharmacology, Drosophila melanogaster/*immunology/microbiology, Drosophila Proteins/*immunology/pharmacology/physiology, Enzyme Activation, Fungal, Fungi, Fungi/*immunology, Hemolymph, Hemolymph/immunology, Melanins, Melanins/*physiology, Monophenol Monooxygenase, Monophenol Monooxygenase/physiology, Multiprotein Complexes, Multiprotein Complexes/physiology, Recombinant Fusion Proteins, Recombinant Fusion Proteins/pharmacology, Serpins, Serpins/physiology, Spores, Toll-Like Receptors, Toll-Like Receptors/immunology

2009

Journal Articles

10.

Garrett, Matthew; Fullaondo, Ane; Troxler, Laurent; Micklem, Gos; Gubb, David

Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes Journal Article

BMC Genomics, 10 , pp. 489, 2009, ISSN: 1471-2164.

Abstract | Links | BibTeX | Tags: bioinformatic, Comparative Genomic Hybridization, Conserved Sequence, DNA, Drosophilidae, Evolution, Genome, Insect, Molecular, Multigene Family, Sequence Alignment, Sequence Analysis, Serpins, Synteny

2007

Incollections

9.

Gubb, David; Robertson, Andrew S; Troxler, Laurent; Reichhart, Jean-Marc

Drosophila Serpins: Regulatory Cascades in Innate Immunity and Morphogenesis Incollection

Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, pp. 207–227, Silverman GA and Lomas DA, London UK, 2007.

BibTeX | Tags: bioinformatic, innate immunity, Morphogenesis, regulatory Cascades, Serpins

2006

Journal Articles

8.

Pelte, Nadège; Robertson, Andrew S; Zou, Zhen; Belorgey, Didier; Dafforn, Timothy R; Jiang, Haobo; Lomas, David; Reichhart, Jean-Marc; Gubb, David

Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic Journal Article

Insect Biochem. Mol. Biol., 36 (1), pp. 37–46, 2006, ISSN: 0965-1748.

Abstract | Links | BibTeX | Tags: Gene Expression Regulation, Protein Conformation, Serpins, Signal Transduction

2005

Journal Articles

7.

Reichhart, Jean-Marc

Tip of another iceberg: Drosophila serpins Journal Article

Trends Cell Biol., 15 (12), pp. 659–665, 2005, ISSN: 0962-8924.

Abstract | Links | BibTeX | Tags: Immunity, Protein Conformation, Serine Proteinase Inhibitors, Serpins

2003

Journal Articles

6.

Ligoxygakis, Petros; Roth, Siegfried; Reichhart, Jean-Marc

A serpin regulates dorsal-ventral axis formation in the Drosophila embryo Journal Article

Curr. Biol., 13 (23), pp. 2097–2102, 2003, ISSN: 0960-9822.

Abstract | BibTeX | Tags: Body Patterning, Cell Surface, Crosses, Female, Genetic, Immunohistochemistry, Microinjections, Receptors, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors

5.

Goto, Akira; Blandin, Stéphanie A; Royet, Julien; Reichhart, Jean-Marc; Levashina, Elena A

Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies Journal Article

Nucleic Acids Res., 31 (22), pp. 6619–6623, 2003, ISSN: 1362-4962.

Abstract | BibTeX | Tags: Cell Surface, Double-Stranded, Epistasis, Female, Genetic, Green Fluorescent Proteins, Homeodomain Proteins, Luminescent Proteins, Phenotype, Receptors, RNA, RNA Interference, Serpins, Signal Transduction, Time Factors, Toll-Like Receptors, Transcription Factors

4.

Green, Clare; Brown, Gemma; Dafforn, Timothy R; Reichhart, Jean-Marc; Morley, Terri; Lomas, David A; Gubb, David

Drosophila necrotic mutations mirror disease-associated variants of human serpins Journal Article

Development, 130 (7), pp. 1473–1478, 2003, ISSN: 0950-1991.

Abstract | BibTeX | Tags: Humans, Necrosis, Serpins, Temperature, Urea

2002

Journal Articles

3.

Ligoxygakis, Petros; Pelte, Nadège ; Ji, Chuanyi ; Leclerc, Vincent ; Duvic, Bernard ; Belvin, Marcia ; Jiang, Haobo ; Hoffmann, Jules A; Reichhart, Jean-Marc

A serpin mutant links Toll activation to melanization in the host defence of Drosophila Journal Article

EMBO J., 21 (23), pp. 6330–6337, 2002, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Cell Surface, Hemolymph, Infection, Melanins, Receptors, Serpins, Toll-Like Receptors

2.

Christophides, George K; Zdobnov, Evgeny; Barillas-Mury, Carolina; Birney, Ewan; Blandin, Stephanie A; Blass, Claudia; Brey, Paul T; Collins, Frank H; Danielli, Alberto; Dimopoulos, George; Hetru, Charles; Hoa, Ngo T; Hoffmann, Jules A; Kanzok, Stefan M; Letunic, Ivica; Levashina, Elena A; Loukeris, Thanasis G; Lycett, Gareth; Meister, Stephan; Michel, Kristin; Moita, Luis F; Müller, Hans-Michael; Osta, Mike A; Paskewitz, Susan M; Reichhart, Jean-Marc; Rzhetsky, Andrey; Troxler, Laurent; Vernick, Kenneth D; Vlachou, Dina; Volz, Jennifer; von Mering, Christian; Xu, Jiannong; Zheng, Liangbiao; Bork, Peer; Kafatos, Fotis C

Immunity-related genes and gene families in Anopheles gambiae Journal Article

Science, 298 (5591), pp. 159–165, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Alternative Splicing, Anopheles, Apoptosis, Bacteria, bioinformatic, Catechol Oxidase, Computational Biology, Enzyme Precursors, Gene Expression Regulation, Genes, Genetic, Genome, Immunity, Innate, Insect, Insect Proteins, Multigene Family, Peptides, Phylogeny, Plasmodium, Protein Structure, Selection, Serine Endopeptidases, Serpins, Signal Transduction, Tertiary

1999

Journal Articles

1.

Levashina, Elena A; Langley, E; Green, C; Gubb, David ; Ashburner, M; Hoffmann, Jules A; Reichhart, Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Journal Article

Science, 285 (5435), pp. 1917–1919, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation