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2016

Book Chapters

33.

Paro, Simona; Imler, Jean-Luc

Encyclopedia of Immunobiology Book Chapter

Ratcliffe, M (Ed.): 1 , Chapter “Immunity in insects”, pp. 454-461, Elsevier, 2016.

BibTeX | Tags: Immunity, Insect

2015

Journal Articles

32.

Veillard, Florian; Troxler, Laurent; Reichhart, Jean-Marc

Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation Journal Article

Biochimie, 122 , pp. 255-269, 2015, ISBN: 0300-9084.

Abstract | Links | BibTeX | Tags: bioinformatic, Chymotrypsin, clip domain, Immunity, Insect, Melanization, Serine Proteases, Serpin, Toll

2013

Journal Articles

31.

Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng; Makino-Okamura, Chieko; Shilova, Victoria; Liu, Xi; Maksoud, Elie; Matsubayashi, Jun; Haddad, Iman; Spirohn, Kerstin; Ono, Kenichiro; Hetru, Charles; Rossier, Jean; Ideker, Trey; Boutros, Michael; Vinh, Joëlle; Hoffmann, Jules A

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (26), pp. 10717–10722, 2013, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Amino Acid, Chromatin Assembly and Disassembly, Escherichia coli, functional proteomics, Genes, Genetically Modified, Histone Acetyltransferases, Host-Pathogen Interactions, Humans, IMD interactome, Insect, Models, Molecular, Protein Interaction Maps, Sequence Homology, Signal Transduction, small ubiquitin-like modifier

2011

Journal Articles

30.

Limmer, Stefanie; Haller, Samantha; Drenkard, Eliana; Lee, Janice; Yu, Shen; Kocks, Christine; Ausubel, Frederick M; Ferrandon, Dominique

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model Journal Article

Proc. Natl. Acad. Sci. U.S.A., 108 (42), pp. 17378–17383, 2011, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Animal, Bacteremia, Bacterial Proteins, Cellular, Disease Models, Genes, Genetically Modified, Hemolymph, Host-Pathogen Interactions, Immunity, Insect, Mutation, Oral, Pseudomonas aeruginosa, Pseudomonas Infections, Quorum Sensing, Trans-Activators, Viral, Virulence

2009

Journal Articles

29.

Garrett, Matthew; Fullaondo, Ane; Troxler, Laurent; Micklem, Gos; Gubb, David

Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes Journal Article

BMC Genomics, 10 , pp. 489, 2009, ISSN: 1471-2164.

Abstract | Links | BibTeX | Tags: bioinformatic, Comparative Genomic Hybridization, Conserved Sequence, DNA, Drosophilidae, Evolution, Genome, Insect, Molecular, Multigene Family, Sequence Alignment, Sequence Analysis, Serpins, Synteny

28.

Cronin, Shane J F; Nehme, Nadine T; Limmer, Stefanie; Liegeois, Samuel; Pospisilik, Andrew J; Schramek, Daniel; Leibbrandt, Andreas; de Simoes, Ricardo Matos; Gruber, Susanne; Puc, Urszula; Ebersberger, Ingo; Zoranovic, Tamara; Neely, Gregory G; von Haeseler, Arndt; Ferrandon, Dominique; Penninger, Josef M

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection Journal Article

Science, 325 (5938), pp. 340–343, 2009, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: *Genome, *RNA Interference, Animal, Cell Proliferation, Drosophila melanogaster/*genetics/immunology/*microbiology, Drosophila Proteins/genetics/metabolism, Epithelial Cells, Epithelial Cells/cytology/physiology, Genetically Modified, Genome, Hemocytes, Hemocytes/immunology/metabolism/microbiology, Homeostasis, Immunity, Innate, Innate/*genetics, Insect, Intestinal Mucosa, Intestinal Mucosa/cytology/immunology/metabolism/microbiology, Janus Kinases, Janus Kinases/genetics/metabolism, Models, RNA Interference, Serratia Infections, Serratia Infections/genetics/*immunology/microbiology, Serratia marcescens, Serratia marcescens/*immunology/physiology, Signal Transduction, STAT Transcription Factors, STAT Transcription Factors/genetics/metabolism, Stem Cells, Stem Cells/cytology/physiology

2006

Journal Articles

27.

Frolet, Cécile; Thoma, Martine; Blandin, Stéphanie A; Hoffmann, Jules A; Levashina, Elena A

Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei Journal Article

Immunity, 25 (4), pp. 677–685, 2006, ISSN: 1074-7613.

Abstract | Links | BibTeX | Tags: Anopheles gambiae, Gene Expression, Gene Expression Regulation, Genes, Immunity, Insect, NF-kappa B, Plasmodium berghei, Telomerase

26.

Evans, J D; Aronstein, K; Chen, Y P; Hetru, Charles; Imler, Jean-Luc; Jiang, H; Kanost, M; Thompson, G J; Zou, Z; Hultmark, D

Immune pathways and defence mechanisms in honey bees Apis mellifera Journal Article

Insect Molecular Biology, 15 (5), pp. 645–656, 2006, ISSN: 0962-1075.

Abstract | Links | BibTeX | Tags: Bees, Carrier Proteins, Genome, Immunity, Insect, Janus Kinases, Multigene Family, Serine Endopeptidases, Signal Transduction, STAT Transcription Factors, Toll-Like Receptors

2005

Journal Articles

25.

Kocks, Christine; Cho, Ju Hyun ; Nehme, Nadine ; Ulvila, Johanna ; Pearson, Alan M; Meister, Marie ; Strom, Charles ; Conto, Stephanie L; Hetru, Charles ; Stuart, Lynda M; Stehle, Thilo ; Hoffmann, Jules A; Reichhart, Jean-Marc ; Ferrandon, Dominique ; Rämet, Mika ; Ezekowitz, Alan R B

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila Journal Article

Cell, 123 (2), pp. 335–346, 2005, ISSN: 0092-8674.

Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid Motifs, Bacterial Infections, Cell Surface, Embryo, Escherichia coli, Flow Cytometry, Frameshift Mutation, Genes, Histidine, In Situ Hybridization, Insect, Insect Proteins, Macrophages, Membrane Proteins, Messenger, Nonmammalian, Open Reading Frames, Phagocytosis, Receptors, RNA, RNA Interference, Sequence Homology, Serratia marcescens

24.

Imler, Jean-Luc; Bulet, Philippe

Antimicrobial peptides in Drosophila: structures, activities and gene regulation Journal Article

Chemical Immunology and Allergy, 86 , pp. 1–21, 2005, ISSN: 1660-2242.

Abstract | Links | BibTeX | Tags: Antimicrobial Cationic Peptides, Defensins, Gene Expression Regulation, Genes, Glycopeptides, Immunity, Innate, Insect, Insect Proteins, Molecular Structure, Signal Transduction

2004

Journal Articles

23.

Blandin, Stéphanie A; Levashina, Elena A

Mosquito immune responses against malaria parasites Journal Article

Curr. Opin. Immunol., 16 (1), pp. 16–20, 2004, ISSN: 0952-7915.

Abstract | BibTeX | Tags: Anopheles, Gene Library, Genes, Hemocytes, Host-Parasite Interactions, Immunity, Innate, Insect, Insect Vectors, Malaria, Plasmodium

2003

Journal Articles

22.

Gobert, Vanessa; Gottar, Marie; Matskevich, Alexey A; Rutschmann, Sophie; Royet, Julien; Belvin, Marcia; Hoffmann, Jules A; Ferrandon, Dominique

Dual activation of the Drosophila toll pathway by two pattern recognition receptors Journal Article

Science, 302 (5653), pp. 2126–2130, 2003, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Carrier Proteins, Cell Surface, DNA Transposable Elements, Gene Expression, Genes, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Hypocreales, Insect, Insect Proteins, Mutation, Phenotype, Receptors, Serine Endopeptidases, Toll-Like Receptors

2002

Journal Articles

21.

Christophides, George K; Zdobnov, Evgeny; Barillas-Mury, Carolina; Birney, Ewan; Blandin, Stephanie A; Blass, Claudia; Brey, Paul T; Collins, Frank H; Danielli, Alberto; Dimopoulos, George; Hetru, Charles; Hoa, Ngo T; Hoffmann, Jules A; Kanzok, Stefan M; Letunic, Ivica; Levashina, Elena A; Loukeris, Thanasis G; Lycett, Gareth; Meister, Stephan; Michel, Kristin; Moita, Luis F; Müller, Hans-Michael; Osta, Mike A; Paskewitz, Susan M; Reichhart, Jean-Marc; Rzhetsky, Andrey; Troxler, Laurent; Vernick, Kenneth D; Vlachou, Dina; Volz, Jennifer; von Mering, Christian; Xu, Jiannong; Zheng, Liangbiao; Bork, Peer; Kafatos, Fotis C

Immunity-related genes and gene families in Anopheles gambiae Journal Article

Science, 298 (5591), pp. 159–165, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Alternative Splicing, Anopheles, Apoptosis, Bacteria, bioinformatic, Catechol Oxidase, Computational Biology, Enzyme Precursors, Gene Expression Regulation, Genes, Genetic, Genome, Immunity, Innate, Insect, Insect Proteins, Multigene Family, Peptides, Phylogeny, Plasmodium, Protein Structure, Selection, Serine Endopeptidases, Serpins, Signal Transduction, Tertiary

20.

Ligoxygakis, Petros; Pelte, Nadège ; Hoffmann, Jules A; Reichhart, Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Journal Article

Science, 297 (5578), pp. 114–116, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, Hypocreales, Insect, Insect Proteins, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, Serine Endopeptidases, Tertiary, Toll-Like Receptors

19.

Ligoxygakis, Petros; Bulet, Philippe; Reichhart, Jean-Marc

Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila Journal Article

EMBO Rep., 3 (7), pp. 666–673, 2002, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Cell Adhesion Molecules, Fat Body, Gene Expression Regulation, Genes, Immunohistochemistry, Immunologic, Insect, Insect Proteins, Larva, Mass, Matrix-Assisted Laser Desorption-Ionization, Membrane Proteins, Receptors, Reporter, Spectrometry, Transgenes

18.

Tauszig-Delamasure, Servane; Bilak, Hana ; Capovilla, Maria ; Hoffmann, Jules A; Imler, Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

Nature Immunology, 3 (1), pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, Hypocreales, Immunologic, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

2001

Journal Articles

17.

Michel, T; Reichhart, Jean-Marc ; Hoffmann, Jules A; Royet, Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Journal Article

Nature, 414 (6865), pp. 756–759, 2001, ISSN: 0028-0836.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, Humans, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, Sequence Homology, Toll-Like Receptors

2000

Journal Articles

16.

Imler, Jean-Luc; Hoffmann, Jules A

Signaling mechanisms in the antimicrobial host defense of Drosophila Journal Article

Current Opinion in Microbiology, 3 (1), pp. 16–22, 2000, ISSN: 1369-5274.

Abstract | BibTeX | Tags: Anti-Infective Agents, Cell Surface, Gene Expression Regulation, Genes, Insect, Insect Proteins, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptors

15.

Meister, Marie; Hetru, Charles; Hoffmann, Jules A

The antimicrobial host defense of Drosophila Journal Article

Curr. Top. Microbiol. Immunol., 248 , pp. 17–36, 2000, ISSN: 0070-217X.

BibTeX | Tags: Anti-Infective Agents, Fat Body, Genes, Insect, Insect Proteins

14.

Tzou, P; Ohresser, S; Ferrandon, Dominique; Capovilla, Maria; Reichhart, Jean-Marc; Lemaitre, Bruno; Hoffmann, Jules A; Imler, Jean-Luc

Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia Journal Article

Immunity, 13 , pp. 737–48., 2000, ISSN: 1074-7613.

Abstract | BibTeX | Tags: *Genes, Animal, Anti-Infective Agents/*immunology/metabolism, Drosophila/genetics/*immunology, Gene Expression Regulation/*immunology, Genes, Glycoside Hydrolases/immunology, Human, Insect, Insect Proteins/genetics/immunology, Non-U.S. Gov't, Organ Specificity, P.H.S., Reporter, Support, Transfection, U.S. Gov't

13.

Imler, Jean-Luc; Tauszig, Servane ; Jouanguy, Emmanuelle ; Forestier, C; Hoffmann, Jules A

LPS-induced immune response in Drosophila Journal Article

Journal of Endotoxin Research, 6 (6), pp. 459–462, 2000, ISSN: 0968-0519.

Abstract | BibTeX | Tags: Biological, Cell Line, Cell Surface, Defensins, Genes, Genetic, Insect, Insect Proteins, Lipopolysaccharides, Membrane Glycoproteins, Models, Mutation, Promoter Regions, Receptors, Signal Transduction, Toll-Like Receptors

1999

Journal Articles

12.

Levashina, Elena A; Langley, E; Green, C; Gubb, David ; Ashburner, M; Hoffmann, Jules A; Reichhart, Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Journal Article

Science, 285 (5435), pp. 1917–1919, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

11.

Manfruelli, P; Reichhart, Jean-Marc ; Steward, R; Hoffmann, Jules A; Lemaitre, Bruno

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF Journal Article

EMBO J., 18 (12), pp. 3380–3391, 1999, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Cell Surface, Clone Cells, DNA-Binding Proteins, Fat Body, Female, Gene Expression Regulation, Genes, Insect, Insect Proteins, Larva, Male, Membrane Glycoproteins, Mosaicism, Mutation, Nuclear Proteins, Phosphoproteins, Receptors, Reporter, Signal Transduction, Toll-Like Receptors, Transcription Factors

1998

Journal Articles

10.

Levashina, Elena A; Ohresser, S; Lemaitre, Bruno; Imler, Jean-Luc

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin Journal Article

Journal of Molecular Biology, 278 (3), pp. 515–527, 1998, ISSN: 0022-2836.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Antimicrobial Cationic Peptides, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Glycopeptides, Insect, Insect Proteins, Larva, Molecular, Mutation, Peptides, Promoter Regions, Recombinant Fusion Proteins, Reporter, Restriction Mapping, Transcription

1997

Journal Articles

9.

Lemaitre, Bruno; Reichhart, Jean-Marc ; Hoffmann, Jules A

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms Journal Article

Proc. Natl. Acad. Sci. U.S.A., 94 (26), pp. 14614–14619, 1997, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Genes, Immunity, Insect, Peptides

8.

Dimarcq, Jean-Luc; Imler, Jean-Luc ; Lanot, R; Ezekowitz, Alan R B; Hoffmann, Jules A; Janeway, C A; Lagueux, Marie

Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression Journal Article

Insect Biochemistry and Molecular Biology, 27 (10), pp. 877–886, 1997, ISSN: 0965-1748.

Abstract | BibTeX | Tags: Bacterial Infections, Cellular, Ecdysone, Gene Expression, Genes, Hemocytes, Hemolymph, Immunity, Insect, Macrophages, Peptide Biosynthesis, Phagocytosis

1996

Journal Articles

7.

Richman, A M; Bulet, Philippe; Hetru, Charles; Barillas-Mury, Carolina; Hoffmann, Jules A; Kafalos, Fotis C

Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA Journal Article

Insect Mol. Biol., 5 (3), pp. 203–210, 1996, ISSN: 0962-1075.

Abstract | BibTeX | Tags: Amino Acid, Anopheles, Base Sequence, Blood Bactericidal Activity, Blood Proteins, Cloning, Complementary, Defensins, DNA, Escherichia coli, Female, Gene Expression, Genes, Insect, Insect Vectors, Larva, Micrococcus luteus, Molecular, Sequence Homology

6.

Lemaitre, Bruno; Nicolas, E; Michaut, Lydia ; Reichhart, Jean-Marc ; Hoffmann, Jules A

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults Journal Article

Cell, 86 (6), pp. 973–983, 1996, ISSN: 0092-8674.

Abstract | BibTeX | Tags: Antifungal Agents, Cell Surface, DNA-Binding Proteins, Fungi, Gene Expression, Genes, Insect, Insect Hormones, Insect Proteins, Membrane Glycoproteins, MHC Class II, Mutation, Mycoses, NF-kappa B, Phosphoproteins, Proteins, Receptors, Signal Transduction, Toll-Like Receptors

1995

Journal Articles

5.

Lemaitre, Bruno; Kromer-Metzger, E; Michaut, Lydia ; Nicolas, E; Meister, Marie ; Georgel, Philippe ; Reichhart, Jean-Marc ; Hoffmann, Jules A

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense Journal Article

Proc. Natl. Acad. Sci. U.S.A., 92 (21), pp. 9465–9469, 1995, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Bacterial Infections, Base Sequence, Gene Expression Regulation, Genes, Glycopeptides, Insect, Insect Hormones, Insect Proteins, Male, Mutation, Mycoses, Nucleic Acid, Peptides, Protein Binding, Recessive, Regulatory Sequences, Reporter, Survival Analysis

4.

Georgel, Philippe; Kappler, Christine ; Langley, E; Gross, I; Nicolas, E; Reichhart, Jean-Marc ; Hoffmann, Jules A

Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter Journal Article

Nucleic Acids Res., 23 (7), pp. 1140–1145, 1995, ISSN: 0305-1048.

Abstract | BibTeX | Tags: Base Sequence, CCAAT-Enhancer-Binding Proteins, DNA, DNA-Binding Proteins, Genes, Genetic, Immunity, Insect, Insect Hormones, Insect Proteins, Interferons, Lipopolysaccharides, NF-kappa B, Nuclear Proteins, Plasmids, Promoter Regions, Up-Regulation

1993

Journal Articles

3.

Hoffmann, Jules A; Hetru, Charles ; Reichhart, Jean-Marc

The humoral antibacterial response of Drosophila Journal Article

FEBS Lett., 325 (1-2), pp. 63–66, 1993, ISSN: 0014-5793.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Base Sequence, Genes, Insect, Insect Hormones, Insect Proteins, Sequence Homology

2.

Kappler, Christine; Meister, Marie ; Lagueux, Marie ; Gateff, E; Hoffmann, Jules A; Reichhart, Jean-Marc

Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila Journal Article

EMBO J., 12 (4), pp. 1561–1568, 1993, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Insect, Insect Hormones, Insect Proteins, Lipopolysaccharides, Messenger, Molecular, NF-kappa B, Nucleic Acid, Oligodeoxyribonucleotides, Promoter Regions, Regulatory Sequences, RNA, Transfection

1.

Reichhart, Jean-Marc; Georgel, Philippe ; Meister, Marie ; Lemaitre, Bruno ; Kappler, Christine ; Hoffmann, Jules A

Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila Journal Article

C. R. Acad. Sci. III, Sci. Vie, 316 (10), pp. 1218–1224, 1993, ISSN: 0764-4469.

Abstract | BibTeX | Tags: Blotting, Cellular, Gene Expression, Genes, Genetic, Immunity, Insect, NF-kappa B, Northern, Translocation, Zygote