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2014

Journal Articles

21.

Haller, Samantha; Limmer, Stefanie; Ferrandon, Dominique

Assessing Pseudomonas virulence with a nonmammalian host: Drosophila melanogaster Journal Article

Methods Mol. Biol., 1149 , pp. 723–740, 2014, ISSN: 1940-6029.

Abstract | Links | BibTeX | Tags: Animal, Antimicrobial Cationic Peptides, Biological Assay, Colony Count, Disease Models, Hemolymph, Host-Pathogen Interactions, Mammals, Microbial, Pseudomonas aeruginosa, Pseudomonas Infections, Reverse Transcriptase Polymerase Chain Reaction, Virulence

20.

Imler, Jean-Luc

Overview of Drosophila immunity: a historical perspective Journal Article

Developmental and Comparative Immunology, 42 (1), pp. 3–15, 2014, ISSN: 1879-0089.

Abstract | Links | BibTeX | Tags: Allergy and Immunology, Animal, Antimicrobial Cationic Peptides, Antimicrobial peptides, History, Humans, IMD pathway, Immunity, Innate, innate immunity, Models, Pattern recognition receptors, Signal Transduction, Toll-Like Receptors

2013

Journal Articles

19.

Baron, Olga Lucia; van West, Pieter; Industri, Benoit; Ponchet, Michel; Dubreuil, Géraldine; Gourbal, Benjamin; Reichhart, Jean-Marc; Coustau, Christine

Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections Journal Article

PLoS Pathog., 9 (12), pp. e1003792, 2013, ISSN: 1553-7374.

Abstract | Links | BibTeX | Tags: Acute-Phase Proteins, Antimicrobial Cationic Peptides, Biomphalaria, Blood Proteins, Carrier Proteins, Cell Membrane, Cell Membrane Permeability, Cloning, Escherichia coli, Female, Immunity, Infection, Maternally-Acquired, Membrane Glycoproteins, Microbial Sensitivity Tests, Molecular, Oomycetes, Recombinant Proteins, Zygote

2011

Journal Articles

18.

Nehme, Nadine T; Quintin, Jessica; Cho, Ju Hyun; Lee, Janice; Lafarge, Marie-Céline; Kocks, Christine; Ferrandon, Dominique

Relative roles of the cellular and humoral responses in the Drosophila host defense against three gram-positive bacterial infections Journal Article

PLoS ONE, 6 (3), pp. e14743, 2011, ISSN: 1932-6203.

Abstract | Links | BibTeX | Tags: Antimicrobial Cationic Peptides, Carrier Proteins, Cell Surface, Cellular, Enterococcus faecalis, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Host-Pathogen Interactions, Humoral, Immunity, Innate, Micrococcus luteus, Opsonin Proteins, Phagocytosis, Receptors, Signal Transduction, Solubility, Staphylococcus aureus

2006

Journal Articles

17.

Bischoff, Vincent; Vignal, Cécile; Duvic, Bernard; Boneca, Ivo G; Hoffmann, Jules A; Royet, Julien

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2 Journal Article

PLoS Pathog., 2 (2), pp. e14, 2006, ISSN: 1553-7374.

Abstract | Links | BibTeX | Tags: Antimicrobial Cationic Peptides, Bacteria, Carrier Proteins, Down-Regulation, Larva, RNA Interference, Signal Transduction

2005

Journal Articles

16.

Royet, Julien; Reichhart, Jean-Marc ; Hoffmann, Jules A

Sensing and signaling during infection in Drosophila Journal Article

Curr. Opin. Immunol., 17 (1), pp. 11–17, 2005, ISSN: 0952-7915.

Abstract | Links | BibTeX | Tags: Antimicrobial Cationic Peptides, Bacterial Infections, Gene Expression Regulation, Genome, Immunity, Innate, Signal Transduction

15.

Imler, Jean-Luc; Bulet, Philippe

Antimicrobial peptides in Drosophila: structures, activities and gene regulation Journal Article

Chemical Immunology and Allergy, 86 , pp. 1–21, 2005, ISSN: 1660-2242.

Abstract | Links | BibTeX | Tags: Antimicrobial Cationic Peptides, Defensins, Gene Expression Regulation, Genes, Glycopeptides, Immunity, Innate, Insect, Insect Proteins, Molecular Structure, Signal Transduction

2003

Journal Articles

14.

Thouzeau, Cécile; Maho, Yvon Le; Froget, Guillaume; Sabatier, Laurence; Bohec, Céline Le; Hoffmann, Jules A; Bulet, Philippe

Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus Journal Article

J. Biol. Chem., 278 (51), pp. 51053–51058, 2003, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Antimicrobial Cationic Peptides, Bacteria, beta-Defensins, Birds, Feeding Behavior, Fungi, Gastrointestinal Contents, Male, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Isoforms, Sequence Alignment, Spectrometry

2002

Journal Articles

13.

Ligoxygakis, Petros; Bulet, Philippe; Reichhart, Jean-Marc

Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila Journal Article

EMBO Rep., 3 (7), pp. 666–673, 2002, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Cell Adhesion Molecules, Fat Body, Gene Expression Regulation, Genes, Immunohistochemistry, Immunologic, Insect, Insect Proteins, Larva, Mass, Matrix-Assisted Laser Desorption-Ionization, Membrane Proteins, Receptors, Reporter, Spectrometry, Transgenes

12.

Tauszig-Delamasure, Servane; Bilak, Hana ; Capovilla, Maria ; Hoffmann, Jules A; Imler, Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

Nature Immunology, 3 (1), pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, Hypocreales, Immunologic, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

2001

Journal Articles

11.

Boulanger, Nathalie; Ehret-Sabatier, Laurence; Brun, R; Zachary, Daniel; Bulet, Philippe; Imler, Jean-Luc

Immune response of Drosophila melanogaster to infection with the flagellate parasite Crithidia spp Journal Article

Insect Biochemistry and Molecular Biology, 31 (2), pp. 129–137, 2001, ISSN: 0965-1748.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Crithidia, Defensins, Gene Expression, Glycopeptides, Hemocytes, Insect Proteins, Phagocytosis

1999

Journal Articles

10.

Levashina, Elena A; Langley, E; Green, C; Gubb, David ; Ashburner, M; Hoffmann, Jules A; Reichhart, Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Journal Article

Science, 285 (5435), pp. 1917–1919, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

1998

Journal Articles

9.

Levashina, Elena A; Ohresser, S; Lemaitre, Bruno; Imler, Jean-Luc

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin Journal Article

Journal of Molecular Biology, 278 (3), pp. 515–527, 1998, ISSN: 0022-2836.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Antimicrobial Cationic Peptides, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Glycopeptides, Insect, Insect Proteins, Larva, Molecular, Mutation, Peptides, Promoter Regions, Recombinant Fusion Proteins, Reporter, Restriction Mapping, Transcription

1996

Journal Articles

8.

Gross, I; Georgel, Philippe ; Kappler, Christine ; Reichhart, Jean-Marc ; Hoffmann, Jules A

Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin Journal Article

Nucleic Acids Res., 24 (7), pp. 1238–1245, 1996, ISSN: 0305-1048.

Abstract | BibTeX | Tags: Antimicrobial Cationic Peptides, Base Sequence, DNA Primers, DNA-Binding Proteins, Gene Expression Regulation, Genetic, Insect Hormones, Insect Proteins, NF-kappa B, Nuclear Proteins, Peptides, Phosphoproteins, Transcription, Transcription Factors, Transcriptional Activation

7.

Fehlbaum, P; Bulet, Philippe; Chernysh, S; Briand, J P; Roussel, J P; Letellier, L; Hetru, Charles; Hoffmann, Jules A

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides Journal Article

Proc. Natl. Acad. Sci. U.S.A., 93 (3), pp. 1221–1225, 1996, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Amino Acid, Amphibian Proteins, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Cyclic, Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Mass Spectrometry, Microbial Sensitivity Tests, Peptides, Ranidae, Sequence Homology, Skin, Structure-Activity Relationship

1995

Journal Articles

6.

Lemaitre, Bruno; Kromer-Metzger, E; Michaut, Lydia ; Nicolas, E; Meister, Marie ; Georgel, Philippe ; Reichhart, Jean-Marc ; Hoffmann, Jules A

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense Journal Article

Proc. Natl. Acad. Sci. U.S.A., 92 (21), pp. 9465–9469, 1995, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Bacterial Infections, Base Sequence, Gene Expression Regulation, Genes, Glycopeptides, Insect, Insect Hormones, Insect Proteins, Male, Mutation, Mycoses, Nucleic Acid, Peptides, Protein Binding, Recessive, Regulatory Sequences, Reporter, Survival Analysis

5.

Levashina, Elena A; Ohresser, S; Bulet, Philippe ; Reichhart, Jean-Marc ; Hetru, Charles ; Hoffmann, Jules A

Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties Journal Article

Eur. J. Biochem., 233 (2), pp. 694–700, 1995, ISSN: 0014-2956.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Antifungal Agents, Antimicrobial Cationic Peptides, Bacteria, Base Sequence, Cells, Chromosome Mapping, Cloning, Cultured, Genetic, Molecular, Peptides, Proline, Transcription

4.

Lemaitre, Bruno; Meister, Marie ; Govind, S; Georgel, Philippe ; Steward, R; Reichhart, Jean-Marc ; Hoffmann, Jules A

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila Journal Article

EMBO J., 14 (3), pp. 536–545, 1995, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Biological Transport, Cell Nucleus, Cell Surface, DNA-Binding Proteins, Fat Body, Gene Expression Regulation, Genetic, Immunity, Immunohistochemistry, Insect Hormones, Insect Proteins, Melanins, Membrane Glycoproteins, Mutation, Neoplasms, Nuclear Proteins, Phosphoproteins, Receptors, Signal Transduction, Toll-Like Receptors, Transcription, Transcription Factors

1994

Journal Articles

3.

Cociancich, S; Dupont, A; Hegy, G; Lanot, R; Holder, F; Hetru, Charles; Hoffmann, Jules A; Bulet, Philippe

Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus Journal Article

Biochem. J., 300 ( Pt 2) , pp. 567–575, 1994, ISSN: 0264-6021.

Abstract | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Proteins, Chromatography, Defensins, Gas Chromatography-Mass Spectrometry, Gel, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Hemolymph, Insect Proteins, Peptides, Sequence Homology

1992

Journal Articles

2.

Bulet, Philippe; Cociancich, S; Reuland, M; Sauber, F; Bischoff, R; Hegy, G; Dorsselaer, Van A; Hetru, Charles; Hoffmann, Jules A

A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata) Journal Article

Eur. J. Biochem., 209 (3), pp. 977–984, 1992, ISSN: 0014-2956.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Bactericidal Activity, Blood Proteins, Defensins, Hemolymph, Insect Proteins, Insects, Larva, Mass Spectrometry, Peptides

1990

Journal Articles

1.

Hoffmann, Jules A; Hoffmann, Danièle

The inducible antibacterial peptides of dipteran insects Journal Article

Res. Immunol., 141 (9), pp. 910–918, 1990, ISSN: 0923-2494.

BibTeX | Tags: Antimicrobial Cationic Peptides, Defensins, Diptera, Gene Expression Regulation, Genetic, Insect Hormones, Insect Proteins, Nucleic Acid, Proteins, Sequence Homology, Transcription