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2014

Journal Articles

32.

Haller, Samantha; Limmer, Stefanie; Ferrandon, Dominique

Assessing Pseudomonas virulence with a nonmammalian host: Drosophila melanogaster Journal Article

Methods Mol. Biol., 1149 , pp. 723–740, 2014, ISSN: 1940-6029.

Abstract | Links | BibTeX | Tags: Animal, Antimicrobial Cationic Peptides, Biological Assay, Colony Count, Disease Models, Hemolymph, Host-Pathogen Interactions, Mammals, Microbial, Pseudomonas aeruginosa, Pseudomonas Infections, Reverse Transcriptase Polymerase Chain Reaction, Virulence

2011

Journal Articles

31.

Limmer, Stefanie; Haller, Samantha; Drenkard, Eliana; Lee, Janice; Yu, Shen; Kocks, Christine; Ausubel, Frederick M; Ferrandon, Dominique

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model Journal Article

Proc. Natl. Acad. Sci. U.S.A., 108 (42), pp. 17378–17383, 2011, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Animal, Bacteremia, Bacterial Proteins, Cellular, Disease Models, Genes, Genetically Modified, Hemolymph, Host-Pathogen Interactions, Immunity, Insect, Mutation, Oral, Pseudomonas aeruginosa, Pseudomonas Infections, Quorum Sensing, Trans-Activators, Viral, Virulence

2010

Journal Articles

30.

Matskevich, Alexey A; Quintin, Jessica; Ferrandon, Dominique

The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll-pathway activation function Journal Article

Eur. J. Immunol., 40 (5), pp. 1244–1254, 2010, ISSN: 1521-4141.

Abstract | Links | BibTeX | Tags: Agglutination, Beauveria, Beauveria/immunology, Candida albicans, Candida albicans/immunology, Carrier Proteins, Carrier Proteins/*immunology/pharmacology, Drosophila melanogaster/*immunology/microbiology, Drosophila Proteins/*immunology/pharmacology/physiology, Enzyme Activation, Fungal, Fungi, Fungi/*immunology, Hemolymph, Hemolymph/immunology, Melanins, Melanins/*physiology, Monophenol Monooxygenase, Monophenol Monooxygenase/physiology, Multiprotein Complexes, Multiprotein Complexes/physiology, Recombinant Fusion Proteins, Recombinant Fusion Proteins/pharmacology, Serpins, Serpins/physiology, Spores, Toll-Like Receptors, Toll-Like Receptors/immunology

2009

Journal Articles

29.

Mishima, Yumiko; Quintin, Jessica; Aimanianda, Vishukumar; Kellenberger, Christine; Coste, Franck; Clavaud, Cecile; Hetru, Charles; Hoffmann, Jules A; Latgé, Jean-Paul; Ferrandon, Dominique; Roussel, Alain

The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors Journal Article

J. Biol. Chem., 284 (42), pp. 28687–28697, 2009, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: beta-Glucans, Bombyx, Carrier Proteins, Crystallography, Fungal Proteins, Hemolymph, Ligands, Molecular Conformation, Mutagenesis, Polysaccharides, Protein Structure, Secondary, Tertiary, X-Ray

28.

Fraiture, Malou; Baxter, Richard H G; Steinert, Stefanie; Chelliah, Yogarany; Frolet, Cécile; Quispe-Tintaya, Wilber; Hoffmann, Jules A; Blandin, Stéphanie A; Levashina, Elena A

Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium Journal Article

Cell Host Microbe, 5 (3), pp. 273–284, 2009, ISSN: 1934-6069.

Abstract | Links | BibTeX | Tags: Anopheles, APL1, Biological, Complement System Proteins, Hemolymph, Immunologic Factors, LRIM1, Models, Plasmodium, Protein Binding, Proteins, TEP1

2007

Journal Articles

27.

Nehme, Nadine T; Liégeois, Samuel; Kele, Beatrix; Giammarinaro, Philippe; Pradel, Elizabeth; Hoffmann, Jules A; Ewbank, Jonathan J; Ferrandon, Dominique

A model of bacterial intestinal infections in Drosophila melanogaster Journal Article

PLoS Pathog., 3 (11), pp. e173, 2007, ISSN: 1553-7374.

Abstract | Links | BibTeX | Tags: Animal, Disease Models, Electron, Fluorescence, Hemolymph, Host-Pathogen Interactions, Immunohistochemistry, Intestines, Microscopy, Reverse Transcriptase Polymerase Chain Reaction, Serratia Infections, Serratia marcescens, Transmission

2006

Journal Articles

26.

Leclerc, Vincent; Pelte, Nadège ; Chamy, Laure El ; Martinelli, Cosimo ; Ligoxygakis, Petros ; Hoffmann, Jules A; Reichhart, Jean-Marc

Prophenoloxidase activation is not required for survival to microbial infections in Drosophila Journal Article

EMBO Rep., 7 (2), pp. 231–235, 2006, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Bacterial Infections, Catechol Oxidase, Enzyme Activation, Enzyme Precursors, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Immunity, Innate, Mutation, Survival Rate

2003

Journal Articles

25.

Gobert, Vanessa; Gottar, Marie; Matskevich, Alexey A; Rutschmann, Sophie; Royet, Julien; Belvin, Marcia; Hoffmann, Jules A; Ferrandon, Dominique

Dual activation of the Drosophila toll pathway by two pattern recognition receptors Journal Article

Science, 302 (5653), pp. 2126–2130, 2003, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Carrier Proteins, Cell Surface, DNA Transposable Elements, Gene Expression, Genes, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Hypocreales, Insect, Insect Proteins, Mutation, Phenotype, Receptors, Serine Endopeptidases, Toll-Like Receptors

24.

Sabatier, Laurence; Jouanguy, Emmanuelle; Dostert, Catherine; Zachary, Daniel; Dimarcq, Jean-Luc; Bulet, Philippe; Imler, Jean-Luc

Pherokine-2 and -3 Journal Article

European journal of biochemistry / FEBS, 270 (16), pp. 3398–3407, 2003, ISSN: 0014-2956.

Abstract | BibTeX | Tags: Antibody Formation, Base Sequence, Hemolymph, Mass, Matrix-Assisted Laser Desorption-Ionization, Spectrometry

2002

Journal Articles

23.

Ligoxygakis, Petros; Pelte, Nadège ; Ji, Chuanyi ; Leclerc, Vincent ; Duvic, Bernard ; Belvin, Marcia ; Jiang, Haobo ; Hoffmann, Jules A; Reichhart, Jean-Marc

A serpin mutant links Toll activation to melanization in the host defence of Drosophila Journal Article

EMBO J., 21 (23), pp. 6330–6337, 2002, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Cell Surface, Hemolymph, Infection, Melanins, Receptors, Serpins, Toll-Like Receptors

22.

Ligoxygakis, Petros; Pelte, Nadège ; Hoffmann, Jules A; Reichhart, Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Journal Article

Science, 297 (5578), pp. 114–116, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, Hypocreales, Insect, Insect Proteins, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, Serine Endopeptidases, Tertiary, Toll-Like Receptors

2001

Journal Articles

21.

Michel, T; Reichhart, Jean-Marc ; Hoffmann, Jules A; Royet, Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Journal Article

Nature, 414 (6865), pp. 756–759, 2001, ISSN: 0028-0836.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, Humans, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, Sequence Homology, Toll-Like Receptors

1999

Journal Articles

20.

Levashina, Elena A; Langley, E; Green, C; Gubb, David ; Ashburner, M; Hoffmann, Jules A; Reichhart, Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Journal Article

Science, 285 (5435), pp. 1917–1919, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

19.

Lamberty, M; Ades, S; Uttenweiler-Joseph, S; Brookhart, G; Bushey, D; Hoffmann, Jules A; Bulet, Philippe

Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity Journal Article

J. Biol. Chem., 274 (14), pp. 9320–9326, 1999, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Amino Acid, Antifungal Agents, Capillary, Chromatography, Defensins, Electrophoresis, Escherichia coli, Hemolymph, High Pressure Liquid, Insect Proteins, Larva, Lepidoptera, Micrococcus luteus, Proteins, Sequence Homology

18.

Lowenberger, C A; Smartt, C T; Bulet, Philippe; Ferdig, M T; Severson, D W; Hoffmann, Jules A; Christensen, B M

Insect immunity: molecular cloning, expression, and characterization of cDNAs and genomic DNA encoding three isoforms of insect defensin in Aedes aegypti Journal Article

Insect Mol. Biol., 8 (1), pp. 107–118, 1999, ISSN: 0962-1075.

Abstract | BibTeX | Tags: Aedes, Amino Acid, Base Sequence, Blotting, Chromosome Mapping, Cloning, Complementary, Defensins, DNA, Gene Expression, Hemolymph, Molecular, Northern, Protein Isoforms, Proteins, Sequence Homology

17.

Lowenberger, C A; Kamal, S; Chiles, J; Paskewitz, S; Bulet, Philippe; Hoffmann, Jules A; Christensen, B M

Mosquito-Plasmodium interactions in response to immune activation of the vector Journal Article

Exp. Parasitol., 91 (1), pp. 59–69, 1999, ISSN: 0014-4894.

Abstract | Links | BibTeX | Tags: Aedes, Anopheles, Culicidae, Defensins, Digestive System, Escherichia coli, Female, Genetic, Hemolymph, Insect Vectors, Messenger, Micrococcus luteus, Plasmodium, Plasmodium berghei, Plasmodium gallinaceum, Proteins, Reverse Transcriptase Polymerase Chain Reaction, RNA, Transcription

1998

Journal Articles

16.

Uttenweiler-Joseph, S; Moniatte, M; Lagueux, Marie; Dorsselaer, Van A; Hoffmann, Jules A; Bulet, Philippe

Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study Journal Article

Proc. Natl. Acad. Sci. U.S.A., 95 (19), pp. 11342–11347, 1998, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Bacteria, Chromatography, Cloning, Hemolymph, High Pressure Liquid, Immunity, Insect Proteins, Mass, Matrix-Assisted Laser Desorption-Ionization, Messenger, Molecular, Peptides, Protein Precursors, RNA, Sequence Analysis, Spectrometry, Time Factors

1997

Journal Articles

15.

Dimarcq, Jean-Luc; Imler, Jean-Luc ; Lanot, R; Ezekowitz, Alan R B; Hoffmann, Jules A; Janeway, C A; Lagueux, Marie

Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression Journal Article

Insect Biochemistry and Molecular Biology, 27 (10), pp. 877–886, 1997, ISSN: 0965-1748.

Abstract | BibTeX | Tags: Bacterial Infections, Cellular, Ecdysone, Gene Expression, Genes, Hemocytes, Hemolymph, Immunity, Insect, Macrophages, Peptide Biosynthesis, Phagocytosis

1996

Journal Articles

14.

Ehret-Sabatier, L; Loew, D; Goyffon, M; Fehlbaum, P; Hoffmann, Jules A; van Dorsselaer, A; Bulet, Philippe

Characterization of novel cysteine-rich antimicrobial peptides from scorpion blood Journal Article

J. Biol. Chem., 271 (47), pp. 29537–29544, 1996, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Chromatography, Cysteine, Electron, Hemolymph, Hemolysis, High Pressure Liquid, Mass Spectrometry, Microscopy, Peptides, Scorpions

1995

Journal Articles

13.

Bulet, Philippe; Hegy, G; Lambert, J; van Dorsselaer, Alan; Hoffmann, Jules A; Hetru, Charles

Insect immunity. The inducible antibacterial peptide diptericin carries two O-glycans necessary for biological activity Journal Article

Biochemistry, 34 (22), pp. 7394–7400, 1995, ISSN: 0006-2960.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Carbohydrate Sequence, Carbohydrates, Diptera, Escherichia coli, Glycopeptides, Hemolymph, Insect Hormones, Insect Proteins, Larva, Mass Spectrometry, Plants, Trisaccharides

1994

Journal Articles

12.

Cociancich, S; Dupont, A; Hegy, G; Lanot, R; Holder, F; Hetru, Charles; Hoffmann, Jules A; Bulet, Philippe

Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus Journal Article

Biochem. J., 300 ( Pt 2) , pp. 567–575, 1994, ISSN: 0264-6021.

Abstract | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Proteins, Chromatography, Defensins, Gas Chromatography-Mass Spectrometry, Gel, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Hemolymph, Insect Proteins, Peptides, Sequence Homology

1992

Journal Articles

11.

Bulet, Philippe; Cociancich, S; Reuland, M; Sauber, F; Bischoff, R; Hegy, G; Dorsselaer, Van A; Hetru, Charles; Hoffmann, Jules A

A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata) Journal Article

Eur. J. Biochem., 209 (3), pp. 977–984, 1992, ISSN: 0014-2956.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Bactericidal Activity, Blood Proteins, Defensins, Hemolymph, Insect Proteins, Insects, Larva, Mass Spectrometry, Peptides

1991

Journal Articles

10.

Bulet, Philippe; Cociancich, S; Dimarcq, Jean-Luc ; Lambert, J; Reichhart, Jean-Marc ; Hoffmann, Danièle ; Hetru, Charles ; Hoffmann, Jules A

Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family Journal Article

J. Biol. Chem., 266 (36), pp. 24520–24525, 1991, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Antibody Formation, Beetles, Blood Bactericidal Activity, Blood Proteins, Chromatography, Defensins, Hemolymph, High Pressure Liquid, Insect Hormones, Insect Proteins

9.

Lepage, P; Bitsch, F; Roecklin, D; Keppi, E; Dimarcq, Jean-Luc; Reichhart, Jean-Marc; Hoffmann, Jules A; Roitsch, C; Dorsselaer, Van A

Determination of disulfide bridges in natural and recombinant insect defensin A Journal Article

Eur. J. Biochem., 196 (3), pp. 735–742, 1991, ISSN: 0014-2956.

Abstract | BibTeX | Tags: Blood Proteins, Defensins, Diptera, Disulfides, Hemolymph, Mass Spectrometry, Recombinant Proteins

1977

Journal Articles

8.

Hoffmann, Danièle; Brehelin, M; Hoffmann, Jules A

First results of the antibacterial defense reactions of Locusta migratoria larva and imago Journal Article

Ann Parasitol Hum Comp, 52 (1), pp. 87–88, 1977, ISSN: 0003-4150.

BibTeX | Tags: Bacillus thuringiensis, Bacteria, Cellular, Grasshoppers, Hematopoietic System, Hemocytes, Hemolymph, Immunity, Larva, Muramidase

1976

Journal Articles

7.

Lagueux, Marie; Hirn, M; de Reggi, M; Hoffmann, Jules A

Ecdysteroid levels and ovarian development in adult female Locust migratoria Journal Article

C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat., 282 (12), pp. 1187–1190, 1976.

Abstract | BibTeX | Tags: Adipose Tissue, Castration, Female, Grasshoppers, Hemolymph, Invertebrate Hormones, Neurosecretory Systems, Oogenesis, Ovary, Oviposition

1975

Journal Articles

6.

Zachary, Daniel; Bréhelin, M; Hoffmann, Jules A

Role of the Journal Article

Cell Tissue Res., 162 (3), pp. 343–348, 1975, ISSN: 0302-766X.

Abstract | BibTeX | Tags: Agglutination, Diptera, Foreign Bodies, Hemolymph, Phagocytosis

1974

Journal Articles

5.

Goltzené, F; Hoffmann, Jules A

Control of haemolymph protein synthesis and oocyte maturation by the corpora allata in female adults of locusta migratoria (Orthoptera): role of the blood-forming tissue Journal Article

Gen. Comp. Endocrinol., 22 (4), pp. 489–498, 1974, ISSN: 0016-6480.

BibTeX | Tags: Disc, Electrophoresis, Female, Grasshoppers, Hematopoietic System, Hemolymph, Ovum, Protein Biosynthesis, Radiation Effects

1973

Journal Articles

4.

Zachary, Daniel; Hoffmann, Jules A

The haemocytes of Calliphora erythrocephala (Meig.) (Diptera) Journal Article

Z Zellforsch Mikrosk Anat, 141 (1), pp. 55–73, 1973, ISSN: 0340-0336.

BibTeX | Tags: Cell Count, Cell Nucleus, Diptera, Electron, Endoplasmic Reticulum, Hemolymph, Hemostasis, Inclusion Bodies, Larva, Lipids, Lysosomes, Microscopy, Mitochondria, Phase-Contrast, Pupa, Radiation Effects

1972

Journal Articles

3.

Zachary, Daniel; Hoffmann, Jules A; Porte, A

A new type of blood cell (the thrombocytoid) in Calliphora erythrocephala Journal Article

C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat., 275 (3), pp. 393–395, 1972.

BibTeX | Tags: Blood Cells, Blood Platelets, Cell Membrane, Cell Nucleus, Cytoplasm, Diptera, Electron, Hemolymph, Microscopy, Phase-Contrast

1970

Journal Articles

2.

Hoffmann, Jules A

Endocrine regulation of production and differentiation of hemocytes in an orthopteran insect: Locusta migratoria migratoroides Journal Article

Gen. Comp. Endocrinol., 15 (2), pp. 198–219, 1970, ISSN: 0016-6480.

BibTeX | Tags: Biological, Blood Cells, Electrocoagulation, Female, Hemolymph, Insects, Male, Metamorphosis, Microscopy, Neurosecretory Systems, Phase-Contrast

1.

Hoffmann, Jules A; Porte, A; Joly, P

On the localization of phenol-oxidase activity in coagulocytes of Locusta migratoria L. (Orthoptera) Journal Article

C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat., 270 (4), pp. 629–631, 1970.

BibTeX | Tags: Catechol Oxidase, Hemolymph, Insects, Tanning