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2014

Journal Articles

21.

Goto, Akira; Fukuyama, Hidehiro ; Imler, Jean-Luc ; Hoffmann, Jules A

The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response Journal Article

The Journal of Biological Chemistry, 289 (30), pp. 20470–20476, 2014, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: Cell Line, Chromatin Assembly and Disassembly, Epistasis, Escherichia coli, Escherichia coli Infections, Genetic, Immunity, Innate, NF-kappa B, Repressor Proteins, Signal Transduction, Transcription Factors

2013

Journal Articles

20.

Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng; Makino-Okamura, Chieko; Shilova, Victoria; Liu, Xi; Maksoud, Elie; Matsubayashi, Jun; Haddad, Iman; Spirohn, Kerstin; Ono, Kenichiro; Hetru, Charles; Rossier, Jean; Ideker, Trey; Boutros, Michael; Vinh, Joëlle; Hoffmann, Jules A

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (26), pp. 10717–10722, 2013, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Amino Acid, Chromatin Assembly and Disassembly, Escherichia coli, functional proteomics, Genes, Genetically Modified, Histone Acetyltransferases, Host-Pathogen Interactions, Humans, IMD interactome, Insect, Models, Molecular, Protein Interaction Maps, Sequence Homology, Signal Transduction, small ubiquitin-like modifier

19.

Kobayashi, Taira; Ogawa, Michinaga; Sanada, Takahito; Mimuro, Hitomi; Kim, Minsoo; Ashida, Hiroshi; Akakura, Reiko; Yoshida, Mitsutaka; Kawalec, Magdalena; Reichhart, Jean-Marc; Mizushima, Tsunehiro; Sasakawa, Chihiro

The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection Journal Article

Cell Host Microbe, 13 (5), pp. 570–583, 2013, ISSN: 1934-6069.

Abstract | Links | BibTeX | Tags: Animal, Bacillary, Bacterial, Bacterial Proteins, Caspases, Cell Death, Cell Line, Disease Models, DNA, Dysentery, Enzyme Inhibitors, Epithelial Cells, Escherichia coli, Gene Knockout Techniques, Guinea Pigs, Host-Pathogen Interactions, Humans, Initiator, Protein Binding, Protein Interaction Mapping, Salmonella typhimurium, Sequence Analysis, Shigella flexneri, Virulence Factors

18.

Baron, Olga Lucia; van West, Pieter; Industri, Benoit; Ponchet, Michel; Dubreuil, Géraldine; Gourbal, Benjamin; Reichhart, Jean-Marc; Coustau, Christine

Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections Journal Article

PLoS Pathog., 9 (12), pp. e1003792, 2013, ISSN: 1553-7374.

Abstract | Links | BibTeX | Tags: Acute-Phase Proteins, Antimicrobial Cationic Peptides, Biomphalaria, Blood Proteins, Carrier Proteins, Cell Membrane, Cell Membrane Permeability, Cloning, Escherichia coli, Female, Immunity, Infection, Maternally-Acquired, Membrane Glycoproteins, Microbial Sensitivity Tests, Molecular, Oomycetes, Recombinant Proteins, Zygote

2009

Journal Articles

17.

Shia, Alice K H; Glittenberg, Marcus; Thompson, Gavin; Weber, Alexander N R; Reichhart, Jean-Marc; Ligoxygakis, Petros

Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes Journal Article

J. Cell. Sci., 122 (Pt 24), pp. 4505–4515, 2009, ISSN: 1477-9137.

Abstract | Links | BibTeX | Tags: Enterococcus faecalis, Escherichia coli, Fat Body, Hemocytes, Larva, Toll-Like Receptors

2005

Journal Articles

16.

Kocks, Christine; Cho, Ju Hyun ; Nehme, Nadine ; Ulvila, Johanna ; Pearson, Alan M; Meister, Marie ; Strom, Charles ; Conto, Stephanie L; Hetru, Charles ; Stuart, Lynda M; Stehle, Thilo ; Hoffmann, Jules A; Reichhart, Jean-Marc ; Ferrandon, Dominique ; Rämet, Mika ; Ezekowitz, Alan R B

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila Journal Article

Cell, 123 (2), pp. 335–346, 2005, ISSN: 0092-8674.

Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid Motifs, Bacterial Infections, Cell Surface, Embryo, Escherichia coli, Flow Cytometry, Frameshift Mutation, Genes, Histidine, In Situ Hybridization, Insect, Insect Proteins, Macrophages, Membrane Proteins, Messenger, Nonmammalian, Open Reading Frames, Phagocytosis, Receptors, RNA, RNA Interference, Sequence Homology, Serratia marcescens

15.

Irving, Phil; Ubeda, Jean-Michel; Doucet, Daniel; Troxler, Laurent; Lagueux, Marie; Zachary, Daniel; Hoffmann, Jules A; Hetru, Charles; Meister, Marie

New insights into Drosophila larval haemocyte functions through genome-wide analysis Journal Article

Cell. Microbiol., 7 (3), pp. 335–350, 2005, ISSN: 1462-5814.

Abstract | Links | BibTeX | Tags: bioinformatic, Catechol Oxidase, Cell Lineage, Enzyme Precursors, Escherichia coli, Fat Body, Gene Expression Profiling, Genome, Hemocytes, Integrin alpha Chains, Integrins, Larva, Micrococcus luteus

2002

Journal Articles

14.

Ligoxygakis, Petros; Pelte, Nadège ; Hoffmann, Jules A; Reichhart, Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Journal Article

Science, 297 (5578), pp. 114–116, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, Hypocreales, Insect, Insect Proteins, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, Serine Endopeptidases, Tertiary, Toll-Like Receptors

13.

Tauszig-Delamasure, Servane; Bilak, Hana ; Capovilla, Maria ; Hoffmann, Jules A; Imler, Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

Nature Immunology, 3 (1), pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, Hypocreales, Immunologic, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

2000

Journal Articles

12.

Hetru, Charles; Letellier, L; Oren, Z; Hoffmann, Jules A; Shai, Y

Androctonin, a hydrophilic disulphide-bridged non-haemolytic anti-microbial peptide: a plausible mode of action Journal Article

Biochem. J., 345 Pt 3 , pp. 653–664, 2000, ISSN: 0264-6021.

Abstract | BibTeX | Tags: Adenosine Triphosphate, Anti-Bacterial Agents, Cations, Cell Membrane Permeability, Cytoplasm, Disulfides, Electron, Escherichia coli, Fluoresceins, Fluorescent Dyes, Fourier Transform Infrared, Gram-Negative Bacteria, Insect Proteins, Liposomes, Microbial Sensitivity Tests, Micrococcus luteus, Microscopy, Oxygen, Phospholipids, Potassium, Proteins, Spectroscopy

1999

Journal Articles

11.

Levashina, Elena A; Langley, E; Green, C; Gubb, David ; Ashburner, M; Hoffmann, Jules A; Reichhart, Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Journal Article

Science, 285 (5435), pp. 1917–1919, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

10.

Lamberty, M; Ades, S; Uttenweiler-Joseph, S; Brookhart, G; Bushey, D; Hoffmann, Jules A; Bulet, Philippe

Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity Journal Article

J. Biol. Chem., 274 (14), pp. 9320–9326, 1999, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Amino Acid, Antifungal Agents, Capillary, Chromatography, Defensins, Electrophoresis, Escherichia coli, Hemolymph, High Pressure Liquid, Insect Proteins, Larva, Lepidoptera, Micrococcus luteus, Proteins, Sequence Homology

9.

Lowenberger, C A; Kamal, S; Chiles, J; Paskewitz, S; Bulet, Philippe; Hoffmann, Jules A; Christensen, B M

Mosquito-Plasmodium interactions in response to immune activation of the vector Journal Article

Exp. Parasitol., 91 (1), pp. 59–69, 1999, ISSN: 0014-4894.

Abstract | Links | BibTeX | Tags: Aedes, Anopheles, Culicidae, Defensins, Digestive System, Escherichia coli, Female, Genetic, Hemolymph, Insect Vectors, Messenger, Micrococcus luteus, Plasmodium, Plasmodium berghei, Plasmodium gallinaceum, Proteins, Reverse Transcriptase Polymerase Chain Reaction, RNA, Transcription

1998

Journal Articles

8.

Braun, A; Hoffmann, Jules A; Meister, Marie

Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes Journal Article

Proc. Natl. Acad. Sci. U.S.A., 95 (24), pp. 14337–14342, 1998, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Adipose Tissue, Candida, Escherichia coli, Fungal, Genotype, Hemocytes, Larva, Melanins, Micrococcus luteus, Spores

1996

Journal Articles

7.

Richman, A M; Bulet, Philippe; Hetru, Charles; Barillas-Mury, Carolina; Hoffmann, Jules A; Kafalos, Fotis C

Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA Journal Article

Insect Mol. Biol., 5 (3), pp. 203–210, 1996, ISSN: 0962-1075.

Abstract | BibTeX | Tags: Amino Acid, Anopheles, Base Sequence, Blood Bactericidal Activity, Blood Proteins, Cloning, Complementary, Defensins, DNA, Escherichia coli, Female, Gene Expression, Genes, Insect, Insect Vectors, Larva, Micrococcus luteus, Molecular, Sequence Homology

6.

Lowenberger, C A; Ferdig, M T; Bulet, Philippe; Khalili, S; Hoffmann, Jules A; Christensen, B M

Aedes aegypti: induced antibacterial proteins reduce the establishment and development of Brugia malayi Journal Article

Exp. Parasitol., 83 (2), pp. 191–201, 1996, ISSN: 0014-4894.

Abstract | Links | BibTeX | Tags: Aedes, Analysis of Variance, Anti-Bacterial Agents, Base Sequence, Blood Proteins, Blotting, Brugia malayi, Culicidae, Defensins, DNA, Escherichia coli, Fat Body, Genetic, Gerbillinae, Micrococcus luteus, Microfilaria, Northern, RNA, Transcription

1995

Journal Articles

5.

Lowenberger, C; Bulet, Philippe; Charlet, Maurice; Hetru, Charles; Hodgeman, B; Christensen, B M; Hoffmann, Jules A

Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti Journal Article

Insect Biochem. Mol. Biol., 25 (7), pp. 867–873, 1995, ISSN: 0965-1748.

Abstract | BibTeX | Tags: Aedes, Amino Acid, Anti-Bacterial Agents, Blood Proteins, Defensins, Escherichia coli, Gram-Negative Bacteria, Gram-Positive Bacteria, Immunity, Insect Vectors, Micrococcus luteus, Sequence Homology, Stereoisomerism

4.

Bulet, Philippe; Hegy, G; Lambert, J; van Dorsselaer, Alan; Hoffmann, Jules A; Hetru, Charles

Insect immunity. The inducible antibacterial peptide diptericin carries two O-glycans necessary for biological activity Journal Article

Biochemistry, 34 (22), pp. 7394–7400, 1995, ISSN: 0006-2960.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Carbohydrate Sequence, Carbohydrates, Diptera, Escherichia coli, Glycopeptides, Hemolymph, Insect Hormones, Insect Proteins, Larva, Mass Spectrometry, Plants, Trisaccharides

1993

Journal Articles

3.

Bulet, Philippe; Dimarcq, Jean-Luc; Hetru, Charles; Lagueux, Marie; Charlet, Maurice; Hegy, G; Dorsselaer, Alan Van; Hoffmann, Jules A

A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution Journal Article

J. Biol. Chem., 268 (20), pp. 14893–14897, 1993, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Base Sequence, Carbohydrates, Cloning, DNA, Escherichia coli, Gas Chromatography-Mass Spectrometry, Glycopeptides, Glycosylation, Molecular

1990

Journal Articles

2.

Wicker, C; Reichhart, Jean-Marc ; Hoffmann, Danièle ; Hultmark, D; Samakovlis, C; Hoffmann, Jules A

Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides Journal Article

J. Biol. Chem., 265 (36), pp. 22493–22498, 1990, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Base Sequence, Cloning, Diptera, DNA, Escherichia coli, Insect Hormones, Insect Proteins, Molecular, Multigene Family, Nucleic Acid, Oligonucleotide Probes, Sequence Homology

1988

Journal Articles

1.

Dimarcq, Jean-Luc; Keppi, E; Dunbar, B; Lambert, J; Reichhart, Jean-Marc ; Hoffmann, Danièle ; Rankine, S M; Fothergill, J E; Hoffmann, Jules A

Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A Journal Article

Eur. J. Biochem., 171 (1-2), pp. 17–22, 1988, ISSN: 0014-2956.

Abstract | BibTeX | Tags: Amino Acids, Anti-Bacterial Agents, Diptera, Escherichia coli, Insect Hormones, Insect Proteins, Isoelectric Point, Larva