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2011

Journal Articles

16.

Limmer, Stefanie; Quintin, Jessica; Hetru, Charles; Ferrandon, Dominique

Virulence on the fly: Drosophila melanogaster as a model genetic organism to decipher host-pathogen interactions Journal Article

Curr Drug Targets, 12 (7), pp. 978–999, 2011, ISSN: 1873-5592.

Abstract | BibTeX | Tags: Animal, Anti-Infective Agents, Disease Models, Drug Delivery Systems, Drug Design, Drug Resistance, Fungi, High-Throughput Screening Assays, Host-Pathogen Interactions, Humans, Microbial, Pseudomonas aeruginosa

2001

Journal Articles

15.

Michel, T; Reichhart, Jean-Marc ; Hoffmann, Jules A; Royet, Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Journal Article

Nature, 414 (6865), pp. 756–759, 2001, ISSN: 0028-0836.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, Humans, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, Sequence Homology, Toll-Like Receptors

14.

Vizioli, J; Bulet, Philippe; Hoffmann, Jules A; Kafatos, Fotis C; Müller, H M; Dimopoulos, G

Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae Journal Article

Proc. Natl. Acad. Sci. U.S.A., 98 (22), pp. 12630–12635, 2001, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: Anopheles, Anti-Bacterial Agents, Anti-Infective Agents, Base Sequence, Chromosome Mapping, Insect Proteins, Insect Vectors, Malaria, Messenger, RNA

13.

Georgel, Philippe; Naitza, S; Kappler, Christine ; Ferrandon, Dominique ; Zachary, Daniel ; Swimmer, C; Kopczynski, C; Duyk, G; Reichhart, Jean-Marc ; Hoffmann, Jules A

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis Journal Article

Dev. Cell, 1 (4), pp. 503–514, 2001, ISSN: 1534-5807.

Abstract | BibTeX | Tags: Anti-Infective Agents, Apoptosis, Bacterial Infections, Caspases, Chromosome Mapping, Cysteine Proteinase Inhibitors, DNA Damage, Female, Gene Expression, I-kappa B Kinase, Immunocompromised Host, In Situ Nick-End Labeling, Insect Proteins, Male, Mutation, Phenotype, Protein Structure, Protein-Serine-Threonine Kinases, Tertiary

2000

Journal Articles

12.

Imler, Jean-Luc; Hoffmann, Jules A

Signaling mechanisms in the antimicrobial host defense of Drosophila Journal Article

Current Opinion in Microbiology, 3 (1), pp. 16–22, 2000, ISSN: 1369-5274.

Abstract | BibTeX | Tags: Anti-Infective Agents, Cell Surface, Gene Expression Regulation, Genes, Insect, Insect Proteins, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptors

11.

Meister, Marie; Hetru, Charles; Hoffmann, Jules A

The antimicrobial host defense of Drosophila Journal Article

Curr. Top. Microbiol. Immunol., 248 , pp. 17–36, 2000, ISSN: 0070-217X.

BibTeX | Tags: Anti-Infective Agents, Fat Body, Genes, Insect, Insect Proteins

1999

Journal Articles

10.

Manfruelli, P; Reichhart, Jean-Marc ; Steward, R; Hoffmann, Jules A; Lemaitre, Bruno

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF Journal Article

EMBO J., 18 (12), pp. 3380–3391, 1999, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Cell Surface, Clone Cells, DNA-Binding Proteins, Fat Body, Female, Gene Expression Regulation, Genes, Insect, Insect Proteins, Larva, Male, Membrane Glycoproteins, Mosaicism, Mutation, Nuclear Proteins, Phosphoproteins, Receptors, Reporter, Signal Transduction, Toll-Like Receptors, Transcription Factors

1998

Journal Articles

9.

Bulet, Philippe; Uttenweiler-Joseph, S; Moniatte, M; Dorsselaer, Van A; Hoffmann, Jules A

Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study Journal Article

J. Protein Chem., 17 (6), pp. 528–529, 1998, ISSN: 0277-8033.

BibTeX | Tags: Anti-Infective Agents, Mass, Matrix-Assisted Laser Desorption-Ionization, Peptide Biosynthesis, Peptides, Spectrometry

8.

Shahabuddin, M; Fields, I; Bulet, Philippe; Hoffmann, Jules A; Miller, L H

Plasmodium gallinaceum: differential killing of some mosquito stages of the parasite by insect defensin Journal Article

Exp. Parasitol., 89 (1), pp. 103–112, 1998, ISSN: 0014-4894.

Abstract | Links | BibTeX | Tags: Aedes, Anti-Infective Agents, Blood Proteins, Defensins, Diptera, Insect Vectors, Insects, Plasmodium gallinaceum, Zygote

7.

Levashina, Elena A; Ohresser, S; Lemaitre, Bruno; Imler, Jean-Luc

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin Journal Article

Journal of Molecular Biology, 278 (3), pp. 515–527, 1998, ISSN: 0022-2836.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Antimicrobial Cationic Peptides, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Glycopeptides, Insect, Insect Proteins, Larva, Molecular, Mutation, Peptides, Promoter Regions, Recombinant Fusion Proteins, Reporter, Restriction Mapping, Transcription

1997

Journal Articles

6.

Meister, Marie; Lemaitre, Bruno; Hoffmann, Jules A

Antimicrobial peptide defense in Drosophila Journal Article

Bioessays, 19 (11), pp. 1019–1026, 1997, ISSN: 0265-9247.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Gene Expression Regulation, Genetic, Insect Proteins, Models, Peptides, Promoter Regions, Signal Transduction

1996

Journal Articles

5.

Charlet, Maurice; Chernysh, S; Philippe, H; Hetru, Charles; Hoffmann, Jules A; Bulet, Philippe

Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis Journal Article

J. Biol. Chem., 271 (36), pp. 21808–21813, 1996, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Amino Acid, Anti-Infective Agents, Antifungal Agents, Bivalvia, Blood Proteins, Chromatography, Cysteine, Defensins, High Pressure Liquid, Molecular Weight, Phylogeny, Sequence Homology

4.

Fehlbaum, P; Bulet, Philippe; Chernysh, S; Briand, J P; Roussel, J P; Letellier, L; Hetru, Charles; Hoffmann, Jules A

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides Journal Article

Proc. Natl. Acad. Sci. U.S.A., 93 (3), pp. 1221–1225, 1996, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Amino Acid, Amphibian Proteins, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Cyclic, Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Mass Spectrometry, Microbial Sensitivity Tests, Peptides, Ranidae, Sequence Homology, Skin, Structure-Activity Relationship

1995

Journal Articles

3.

Lemaitre, Bruno; Meister, Marie ; Govind, S; Georgel, Philippe ; Steward, R; Reichhart, Jean-Marc ; Hoffmann, Jules A

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila Journal Article

EMBO J., 14 (3), pp. 536–545, 1995, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Biological Transport, Cell Nucleus, Cell Surface, DNA-Binding Proteins, Fat Body, Gene Expression Regulation, Genetic, Immunity, Immunohistochemistry, Insect Hormones, Insect Proteins, Melanins, Membrane Glycoproteins, Mutation, Neoplasms, Nuclear Proteins, Phosphoproteins, Receptors, Signal Transduction, Toll-Like Receptors, Transcription, Transcription Factors

1994

Journal Articles

2.

Meister, Marie; Braun, A; Kappler, Christine ; Reichhart, Jean-Marc ; Hoffmann, Jules A

Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter Journal Article

EMBO J., 13 (24), pp. 5958–5966, 1994, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Infective Agents, Base Sequence, beta-Galactosidase, DNA Mutational Analysis, Female, Gene Expression Regulation, Genetic, Genetically Modified, Germ Cells, Insect Hormones, Insect Proteins, Male, Models, Nucleic Acid, Promoter Regions, Recombinant Fusion Proteins, Repetitive Sequences, Transformation

1993

Journal Articles

1.

Georgel, Philippe; Meister, Marie ; Kappler, Christine ; Lemaitre, Bruno ; Reichhart, Jean-Marc ; Hoffmann, Jules A

Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements Journal Article

Biochem. Biophys. Res. Commun., 197 (2), pp. 508–517, 1993, ISSN: 0006-291X.

Abstract | Links | BibTeX | Tags: Acute-Phase Proteins, Anti-Infective Agents, Base Sequence, Cell Line, Deoxyribonuclease I, DNA-Binding Proteins, Genetic, Insect Hormones, Insect Proteins, Larva, Mammals, NF-kappa B, Nucleic Acid, Oligonucleotide Probes, Polymerase Chain Reaction, Promoter Regions, Regulatory Sequences