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2013

Journal Articles

23.

Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng; Makino-Okamura, Chieko; Shilova, Victoria; Liu, Xi; Maksoud, Elie; Matsubayashi, Jun; Haddad, Iman; Spirohn, Kerstin; Ono, Kenichiro; Hetru, Charles; Rossier, Jean; Ideker, Trey; Boutros, Michael; Vinh, Joëlle; Hoffmann, Jules A

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (26), pp. 10717–10722, 2013, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Amino Acid, Chromatin Assembly and Disassembly, Escherichia coli, functional proteomics, Genes, Genetically Modified, Histone Acetyltransferases, Host-Pathogen Interactions, Humans, IMD interactome, Insect, Models, Molecular, Protein Interaction Maps, Sequence Homology, Signal Transduction, small ubiquitin-like modifier

2012

Journal Articles

22.

Liu, Xi; Sano, Teruyuki; Guan, Yongsheng; Nagata, Shigekazu; Hoffmann, Jules A; Fukuyama, Hidehiro

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif Journal Article

PLoS ONE, 7 (8), pp. e42725, 2012, ISSN: 1932-6203.

Abstract | Links | BibTeX | Tags: Amino Acid, Blotting, Conserved Sequence, Endodeoxyribonucleases, Eye Proteins, Immunoprecipitation, Phosphoprotein Phosphatases, Sequence Homology, Transcription Factors, Western

2010

Journal Articles

21.

Garcia, Alvaro Baeza; Pierce, Raymond J; Gourbal, Benjamin; Werkmeister, Elisabeth; Colinet, Dominique; Reichhart, Jean-Marc; Dissous, Colette; Coustau, Christine

Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni Journal Article

PLoS Pathog., 6 (9), pp. e1001115, 2010, ISSN: 1553-7374.

Abstract | Links | BibTeX | Tags: Amino Acid, Apoptosis, Biomphalaria, Blotting, Cell Proliferation, Cells, Cricetinae, Cultured, Hemocytes, Host-Parasite Interactions, Humans, Liver, Macrophage Migration-Inhibitory Factors, Messenger, Oocysts, Recombinant Proteins, Reverse Transcriptase Polymerase Chain Reaction, RNA, Schistosoma mansoni, Schistosomiasis mansoni, Sequence Homology, Small Interfering, Western

2008

Journal Articles

20.

Deddouche, Safia; Matt, Nicolas ; Budd, Aidan ; Mueller, Stefanie ; Kemp, Cordula ; Galiana-Arnoux, Delphine ; Dostert, Catherine ; Antoniewski, Christophe ; Hoffmann, Jules A; Imler, Jean-Luc

The DExD/Ħ-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila Journal Article

Nature Immunology, 9 (12), pp. 1425–1432, 2008, ISSN: 1529-2916.

Abstract | Links | BibTeX | Tags: Amino Acid, Electrophoresis, Fat Body, Gene Expression Regulation, Genetic, Genetically Modified, Humans, Phylogeny, Polyacrylamide Gel, Reverse Transcriptase Polymerase Chain Reaction, Ribonuclease III, RNA Helicases, Sequence Homology, Transcription, Virus Diseases

2005

Journal Articles

19.

Kocks, Christine; Cho, Ju Hyun ; Nehme, Nadine ; Ulvila, Johanna ; Pearson, Alan M; Meister, Marie ; Strom, Charles ; Conto, Stephanie L; Hetru, Charles ; Stuart, Lynda M; Stehle, Thilo ; Hoffmann, Jules A; Reichhart, Jean-Marc ; Ferrandon, Dominique ; Rämet, Mika ; Ezekowitz, Alan R B

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila Journal Article

Cell, 123 (2), pp. 335–346, 2005, ISSN: 0092-8674.

Abstract | Links | BibTeX | Tags: Amino Acid, Amino Acid Motifs, Bacterial Infections, Cell Surface, Embryo, Escherichia coli, Flow Cytometry, Frameshift Mutation, Genes, Histidine, In Situ Hybridization, Insect, Insect Proteins, Macrophages, Membrane Proteins, Messenger, Nonmammalian, Open Reading Frames, Phagocytosis, Receptors, RNA, RNA Interference, Sequence Homology, Serratia marcescens

18.

Weber, Alexander N R; Moncrieffe, Martin C; Gangloff, Monique; Imler, Jean-Luc; Gay, Nicholas J

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway Journal Article

The Journal of Biological Chemistry, 280 (24), pp. 22793–22799, 2005, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Amino Acid, Biophysical Phenomena, Biophysics, Body Patterning, Calorimetry, Cell Line, Cell Surface, Cross-Linking Reagents, Cytokines, Dimerization, Electrophoresis, Humans, Ligands, Luciferases, Membrane Glycoproteins, Polyacrylamide Gel, Protein Binding, Protein Structure, Receptors, Recombinant Proteins, Sequence Homology, Signal Transduction, Tertiary, Time Factors, Toll-Like Receptors, Ultracentrifugation

2002

Journal Articles

17.

Tauszig-Delamasure, Servane; Bilak, Hana ; Capovilla, Maria ; Hoffmann, Jules A; Imler, Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

Nature Immunology, 3 (1), pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, Hypocreales, Immunologic, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

2001

Journal Articles

16.

Michel, T; Reichhart, Jean-Marc ; Hoffmann, Jules A; Royet, Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Journal Article

Nature, 414 (6865), pp. 756–759, 2001, ISSN: 0028-0836.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, Humans, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, Sequence Homology, Toll-Like Receptors

15.

Lamberty, M; Zachary, Daniel; Lanot, R; Bordereau, C; Robert, A; Hoffmann, Jules A; Bulet, Philippe

Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect. Journal Article

J. Biol. Chem., 276 (6), pp. 4085–4092, 2001, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Antifungal Agents, Base Sequence, Chromatography, Cysteine, DNA Primers, High Pressure Liquid, Immunohistochemistry, Isoptera, Peptides, Protein Conformation, Recombinant Proteins, Sequence Homology

2000

Journal Articles

14.

Lagueux, Marie; Perrodou, E; Levashina, Elena A; Capovilla, Maria; Hoffmann, Jules A

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila Journal Article

Proc. Natl. Acad. Sci. U.S.A., 97 (21), pp. 11427–11432, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: alpha-Macroglobulins, Amino Acid, Cell Surface, Complement C3, Esters, Genetic, Insect Proteins, Janus Kinases, Membrane Glycoproteins, Mutation, Protein-Tyrosine Kinases, Proteins, Receptors, Sequence Homology, Sulfhydryl Compounds, Toll-Like Receptors, Transcription, Transcription Factors

13.

Tauszig, Servane; Jouanguy, Emmanuelle ; Hoffmann, Jules A; Imler, Jean-Luc

Toll-related receptors and the control of antimicrobial peptide expression in Drosophila Journal Article

Proceedings of the National Academy of Sciences of the United States of America, 97 (19), pp. 10520–10525, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Blotting, Cell Line, Cell Surface, Membrane Glycoproteins, Multigene Family, Northern, Peptides, Receptors, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptors

1999

Journal Articles

12.

Lamberty, M; Ades, S; Uttenweiler-Joseph, S; Brookhart, G; Bushey, D; Hoffmann, Jules A; Bulet, Philippe

Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity Journal Article

J. Biol. Chem., 274 (14), pp. 9320–9326, 1999, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Amino Acid, Antifungal Agents, Capillary, Chromatography, Defensins, Electrophoresis, Escherichia coli, Hemolymph, High Pressure Liquid, Insect Proteins, Larva, Lepidoptera, Micrococcus luteus, Proteins, Sequence Homology

11.

Lowenberger, C A; Smartt, C T; Bulet, Philippe; Ferdig, M T; Severson, D W; Hoffmann, Jules A; Christensen, B M

Insect immunity: molecular cloning, expression, and characterization of cDNAs and genomic DNA encoding three isoforms of insect defensin in Aedes aegypti Journal Article

Insect Mol. Biol., 8 (1), pp. 107–118, 1999, ISSN: 0962-1075.

Abstract | BibTeX | Tags: Aedes, Amino Acid, Base Sequence, Blotting, Chromosome Mapping, Cloning, Complementary, Defensins, DNA, Gene Expression, Hemolymph, Molecular, Northern, Protein Isoforms, Proteins, Sequence Homology

1998

Journal Articles

10.

Taguchi, S; Bulet, Philippe; Hoffmann, Jules A

A novel insect defensin from the ant Formica rufa Journal Article

Biochimie, 80 (4), pp. 343–346, 1998, ISSN: 0300-9084.

Abstract | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Ants, Chromatography, High Pressure Liquid, Insect Proteins, Insects, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Structure, Secondary, Sequence Alignment, Sequence Homology, Spectrometry

1996

Journal Articles

9.

Barillas-Mury, Carolina; Charlesworth, A; Gross, I; Richman, A; Hoffmann, Jules A; Kafatos, Fotis C

Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae Journal Article

EMBO J., 15 (17), pp. 4691–4701, 1996, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Amino Acid, Anopheles, Base Sequence, Biological Transport, Cell Nucleus, Cells, Complementary, Cultured, DNA, DNA-Binding Proteins, Insect Proteins, Insect Vectors, NF-kappa B, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-rel, Sequence Homology, Trans-Activators, Transcriptional Activation

8.

Charlet, Maurice; Chernysh, S; Philippe, H; Hetru, Charles; Hoffmann, Jules A; Bulet, Philippe

Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis Journal Article

J. Biol. Chem., 271 (36), pp. 21808–21813, 1996, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Amino Acid, Anti-Infective Agents, Antifungal Agents, Bivalvia, Blood Proteins, Chromatography, Cysteine, Defensins, High Pressure Liquid, Molecular Weight, Phylogeny, Sequence Homology

7.

Richman, A M; Bulet, Philippe; Hetru, Charles; Barillas-Mury, Carolina; Hoffmann, Jules A; Kafalos, Fotis C

Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA Journal Article

Insect Mol. Biol., 5 (3), pp. 203–210, 1996, ISSN: 0962-1075.

Abstract | BibTeX | Tags: Amino Acid, Anopheles, Base Sequence, Blood Bactericidal Activity, Blood Proteins, Cloning, Complementary, Defensins, DNA, Escherichia coli, Female, Gene Expression, Genes, Insect, Insect Vectors, Larva, Micrococcus luteus, Molecular, Sequence Homology

6.

Fehlbaum, P; Bulet, Philippe; Chernysh, S; Briand, J P; Roussel, J P; Letellier, L; Hetru, Charles; Hoffmann, Jules A

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides Journal Article

Proc. Natl. Acad. Sci. U.S.A., 93 (3), pp. 1221–1225, 1996, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Amino Acid, Amphibian Proteins, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Cyclic, Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Mass Spectrometry, Microbial Sensitivity Tests, Peptides, Ranidae, Sequence Homology, Skin, Structure-Activity Relationship

1995

Journal Articles

5.

Lowenberger, C; Bulet, Philippe; Charlet, Maurice; Hetru, Charles; Hodgeman, B; Christensen, B M; Hoffmann, Jules A

Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti Journal Article

Insect Biochem. Mol. Biol., 25 (7), pp. 867–873, 1995, ISSN: 0965-1748.

Abstract | BibTeX | Tags: Aedes, Amino Acid, Anti-Bacterial Agents, Blood Proteins, Defensins, Escherichia coli, Gram-Negative Bacteria, Gram-Positive Bacteria, Immunity, Insect Vectors, Micrococcus luteus, Sequence Homology, Stereoisomerism

4.

Cornet, B; Bonmatin, J M; Hetru, Charles; Hoffmann, Jules A; Ptak, M; Vovelle, F

Refined three-dimensional solution structure of insect defensin A Journal Article

Structure, 3 (5), pp. 435–448, 1995, ISSN: 0969-2126.

Abstract | BibTeX | Tags: Amino Acid, Bacteriolysis, Chemistry, Defensins, Diptera, Gram-Positive Bacteria, Hydrogen Bonding, Insect Hormones, Magnetic Resonance Spectroscopy, Models, Molecular, Physical, Physicochemical Phenomena, Protein Conformation, Recombinant Proteins, Sequence Homology, Solutions, Structure-Activity Relationship

1994

Journal Articles

3.

Fehlbaum, P; Bulet, Philippe; Michaut, L; Lagueux, Marie; Broekaert, W F; Hetru, Charles; Hoffmann, Jules A

Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides Journal Article

J. Biol. Chem., 269 (52), pp. 33159–33163, 1994, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Amino Acid, Antifungal Agents, Base Sequence, Cloning, Complementary, DNA, Insect Proteins, Male, Messenger, Microbial Sensitivity Tests, Molecular, Peptide Biosynthesis, Peptides, Plants, Protein Biosynthesis, Protein Precursors, Proteins, RNA, Sequence Homology

2.

Cociancich, S; Dupont, A; Hegy, G; Lanot, R; Holder, F; Hetru, Charles; Hoffmann, Jules A; Bulet, Philippe

Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus Journal Article

Biochem. J., 300 ( Pt 2) , pp. 567–575, 1994, ISSN: 0264-6021.

Abstract | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Proteins, Chromatography, Defensins, Gas Chromatography-Mass Spectrometry, Gel, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Hemolymph, Insect Proteins, Peptides, Sequence Homology

1992

Journal Articles

1.

Hoffmann, Jules A; Hetru, Charles

Insect defensins: inducible antibacterial peptides Journal Article

Immunol. Today, 13 (10), pp. 411–415, 1992, ISSN: 0167-5699.

Abstract | Links | BibTeX | Tags: Amino Acid, Bacterial Infections, Blood Bactericidal Activity, Blood Proteins, Defensins, Insects, Peptides, Sequence Homology