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2013

Journal Articles

16.

Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng; Makino-Okamura, Chieko; Shilova, Victoria; Liu, Xi; Maksoud, Elie; Matsubayashi, Jun; Haddad, Iman; Spirohn, Kerstin; Ono, Kenichiro; Hetru, Charles; Rossier, Jean; Ideker, Trey; Boutros, Michael; Vinh, Joëlle; Hoffmann, Jules A

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (26), pp. 10717–10722, 2013, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Amino Acid, Chromatin Assembly and Disassembly, Escherichia coli, functional proteomics, Genes, Genetically Modified, Histone Acetyltransferases, Host-Pathogen Interactions, Humans, IMD interactome, Insect, Models, Molecular, Protein Interaction Maps, Sequence Homology, Signal Transduction, small ubiquitin-like modifier

15.

Kemp, Cordula; Mueller, Stefanie ; Goto, Akira ; Barbier, Vincent ; Paro, Simona ; Bonnay, François ; Dostert, Catherine ; Troxler, Laurent ; Hetru, Charles ; Meignin, Carine ; Pfeffer, Sébastien ; Hoffmann, Jules A; Imler, Jean-Luc

Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila Journal Article

Journal of Immunology (Baltimore, Md.: 1950), 190 (2), pp. 650–658, 2013, ISSN: 1550-6606.

Abstract | Links | BibTeX | Tags: Alphavirus, Alphavirus Infections, bioinformatic, DNA Virus Infections, Gene Expression Regulation, Genetically Modified, Janus Kinases, Male, Nodaviridae, Ribonuclease III, RNA Helicases, RNA Interference, RNA Virus Infections, Transcription Factors

2011

Journal Articles

14.

Limmer, Stefanie; Haller, Samantha; Drenkard, Eliana; Lee, Janice; Yu, Shen; Kocks, Christine; Ausubel, Frederick M; Ferrandon, Dominique

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model Journal Article

Proc. Natl. Acad. Sci. U.S.A., 108 (42), pp. 17378–17383, 2011, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Animal, Bacteremia, Bacterial Proteins, Cellular, Disease Models, Genes, Genetically Modified, Hemolymph, Host-Pathogen Interactions, Immunity, Insect, Mutation, Oral, Pseudomonas aeruginosa, Pseudomonas Infections, Quorum Sensing, Trans-Activators, Viral, Virulence

2009

Journal Articles

13.

Cronin, Shane J F; Nehme, Nadine T; Limmer, Stefanie; Liegeois, Samuel; Pospisilik, Andrew J; Schramek, Daniel; Leibbrandt, Andreas; de Simoes, Ricardo Matos; Gruber, Susanne; Puc, Urszula; Ebersberger, Ingo; Zoranovic, Tamara; Neely, Gregory G; von Haeseler, Arndt; Ferrandon, Dominique; Penninger, Josef M

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection Journal Article

Science, 325 (5938), pp. 340–343, 2009, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: *Genome, *RNA Interference, Animal, Cell Proliferation, Drosophila melanogaster/*genetics/immunology/*microbiology, Drosophila Proteins/genetics/metabolism, Epithelial Cells, Epithelial Cells/cytology/physiology, Genetically Modified, Genome, Hemocytes, Hemocytes/immunology/metabolism/microbiology, Homeostasis, Immunity, Innate, Innate/*genetics, Insect, Intestinal Mucosa, Intestinal Mucosa/cytology/immunology/metabolism/microbiology, Janus Kinases, Janus Kinases/genetics/metabolism, Models, RNA Interference, Serratia Infections, Serratia Infections/genetics/*immunology/microbiology, Serratia marcescens, Serratia marcescens/*immunology/physiology, Signal Transduction, STAT Transcription Factors, STAT Transcription Factors/genetics/metabolism, Stem Cells, Stem Cells/cytology/physiology

12.

Berry, Bassam; Deddouche, Safia ; Kirschner, Doris ; Imler, Jean-Luc ; Antoniewski, Christophe

Viral suppressors of RNA silencing hinder exogenous and endogenous small RNA pathways in Drosophila Journal Article

PloS One, 4 (6), pp. e5866, 2009, ISSN: 1932-6203.

Abstract | Links | BibTeX | Tags: Antiviral Agents, Crosses, Double-Stranded, Gene Silencing, Genetic, Genetically Modified, Heterozygote, Invertebrate, Photoreceptor Cells, Reverse Transcriptase Polymerase Chain Reaction, RNA, RNA Interference, Transgenes

2008

Journal Articles

11.

Deddouche, Safia; Matt, Nicolas ; Budd, Aidan ; Mueller, Stefanie ; Kemp, Cordula ; Galiana-Arnoux, Delphine ; Dostert, Catherine ; Antoniewski, Christophe ; Hoffmann, Jules A; Imler, Jean-Luc

The DExD/Ħ-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila Journal Article

Nature Immunology, 9 (12), pp. 1425–1432, 2008, ISSN: 1529-2916.

Abstract | Links | BibTeX | Tags: Amino Acid, Electrophoresis, Fat Body, Gene Expression Regulation, Genetic, Genetically Modified, Humans, Phylogeny, Polyacrylamide Gel, Reverse Transcriptase Polymerase Chain Reaction, Ribonuclease III, RNA Helicases, Sequence Homology, Transcription, Virus Diseases

10.

Chamy, Laure El; Leclerc, Vincent; Caldelari, Isabelle; Reichhart, Jean-Marc

Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll Journal Article

Nat. Immunol., 9 (10), pp. 1165–1170, 2008, ISSN: 1529-2916.

Abstract | Links | BibTeX | Tags: Fungi, Genetically Modified, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, In Situ Hybridization, Mycoses, Pattern Recognition, Peptide Hydrolases, Receptors, Serine Endopeptidases, Signal Transduction, Toll-Like Receptors

2006

Journal Articles

9.

Galiana-Arnoux, Delphine; Dostert, Catherine ; Schneemann, Anette ; Hoffmann, Jules A; Imler, Jean-Luc

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila Journal Article

Nature Immunology, 7 (6), pp. 590–597, 2006, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Genetically Modified, Mutation, Nodaviridae, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Viruses, Viral, Viral Proteins, Virus Replication

2005

Journal Articles

8.

Dostert, Catherine; Jouanguy, Emmanuelle ; Irving, Phil ; Troxler, Laurent ; Galiana-Arnoux, Delphine ; Hetru, Charles ; Hoffmann, Jules A; Imler, Jean-Luc

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila Journal Article

Nature Immunology, 6 (9), pp. 946–953, 2005, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: bioinformatic, DNA-Binding Proteins, Genetic, Genetically Modified, Insect Viruses, Janus Kinase 1, Male, Oligonucleotide Array Sequence Analysis, Promoter Regions, Protein-Tyrosine Kinases, Signal Transduction, STAT1 Transcription Factor, Trans-Activators

2003

Journal Articles

7.

Kambris, Zakaria; Bilak, Hana; D'Alessandro, Rosalba; Belvin, Marcia; Imler, Jean-Luc; Capovilla, Maria

DmMyD88 controls dorsoventral patterning of the Drosophila embryo Journal Article

EMBO reports, 4 (1), pp. 64–69, 2003, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Alleles, Antigens, Base Sequence, Cell Surface, Complementary, Developmental, Differentiation, DNA, DNA Transposable Elements, Egg Proteins, Embryo, Exons, Female, Gene Expression Regulation, Genetically Modified, Genotype, Immunity, Immunologic, Innate, Insertional, Male, Messenger, Morphogenesis, Mutagenesis, Myeloid Differentiation Factor 88, Nonmammalian, Oocytes, Protein Biosynthesis, Protein Structure, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transducing, Tertiary, Toll-Like Receptors, Zygote

2002

Journal Articles

6.

Reichhart, Jean-Marc; Ligoxygakis, Petros ; Naitza, Silvia ; Woerfel, Gertrud ; Imler, Jean-Luc ; Gubb, David

Splice-activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in Drosophila melanogaster Journal Article

Genesis (New York, N.Y.: 2000), 34 (1-2), pp. 160–164, 2002, ISSN: 1526-954X.

Links | BibTeX | Tags: DNA Transposable Elements, DNA-Binding Proteins, Enhancer Elements, Genetic, Genetic Vectors, Genetically Modified, Saccharomyces cerevisiae Proteins, Transcription Factors

5.

Tauszig-Delamasure, Servane; Bilak, Hana ; Capovilla, Maria ; Hoffmann, Jules A; Imler, Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

Nature Immunology, 3 (1), pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, Hypocreales, Immunologic, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

2000

Journal Articles

4.

Basset, A; Khush, R S; Braun, A; Gardan, L; Boccard, F; Hoffmann, Jules A; Lemaitre, Bruno

The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response Journal Article

Proc. Natl. Acad. Sci. U.S.A., 97 (7), pp. 3376–3381, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: Bacterial, Gene Expression Regulation, Genetically Modified, Insect Proteins, Larva, Pectobacterium carotovorum

1998

Journal Articles

3.

Levashina, Elena A; Ohresser, S; Lemaitre, Bruno; Imler, Jean-Luc

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin Journal Article

Journal of Molecular Biology, 278 (3), pp. 515–527, 1998, ISSN: 0022-2836.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Antimicrobial Cationic Peptides, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Glycopeptides, Insect, Insect Proteins, Larva, Molecular, Mutation, Peptides, Promoter Regions, Recombinant Fusion Proteins, Reporter, Restriction Mapping, Transcription

1994

Journal Articles

2.

Meister, Marie; Braun, A; Kappler, Christine ; Reichhart, Jean-Marc ; Hoffmann, Jules A

Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter Journal Article

EMBO J., 13 (24), pp. 5958–5966, 1994, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Infective Agents, Base Sequence, beta-Galactosidase, DNA Mutational Analysis, Female, Gene Expression Regulation, Genetic, Genetically Modified, Germ Cells, Insect Hormones, Insect Proteins, Male, Models, Nucleic Acid, Promoter Regions, Recombinant Fusion Proteins, Repetitive Sequences, Transformation

1993

Journal Articles

1.

Kappler, Christine; Meister, Marie ; Lagueux, Marie ; Gateff, E; Hoffmann, Jules A; Reichhart, Jean-Marc

Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila Journal Article

EMBO J., 12 (4), pp. 1561–1568, 1993, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Insect, Insect Hormones, Insect Proteins, Lipopolysaccharides, Messenger, Molecular, NF-kappa B, Nucleic Acid, Oligodeoxyribonucleotides, Promoter Regions, Regulatory Sequences, RNA, Transfection