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2014

Journal Articles

22.

Bonnay, François; Nguyen, Xuan-Hung; Cohen-Berros, Eva; Troxler, Laurent; Batsche, Eric; Camonis, Jacques; Takeuchi, Osamu; Reichhart, Jean-Marc; Matt, Nicolas

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling Journal Article

EMBO J., 33 (20), pp. 2349–2362, 2014, ISSN: 1460-2075.

Abstract | Links | BibTeX | Tags: bioinformatic, Cell Cycle Proteins, Chromatin Assembly and Disassembly, chromatin remodeling, DNA-Binding Proteins, Female, Genetic, Immunity, Innate, Innate immune response, Male, Mutation, NF-kappa B, NF‐κB, Promoter Regions, Proteomics, Trans-Activators, Transcription Factors, Transcriptional Activation, Two-Hybrid System Techniques

2013

Journal Articles

21.

Ayyaz, Arshad; Giammarinaro, Philippe; Liégeois, Samuel; Lestradet, Matthieu; Ferrandon, Dominique

A negative role for MyD88 in the resistance to starvation as revealed in an intestinal infection of Drosophila melanogaster with the Gram-positive bacterium Staphylococcus xylosus Journal Article

Immunobiology, 218 (4), pp. 635–644, 2013, ISSN: 1878-3279.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Animal, Antigens, Differentiation, Disease Models, Immunity, Immunologic, Innate, Intestinal Diseases, Mucosal, Mutation, Receptors, Signal Transducing, Staphylococcal Infections, Staphylococcus, Starvation, Toll-Like Receptors

2011

Journal Articles

20.

Limmer, Stefanie; Haller, Samantha; Drenkard, Eliana; Lee, Janice; Yu, Shen; Kocks, Christine; Ausubel, Frederick M; Ferrandon, Dominique

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model Journal Article

Proc. Natl. Acad. Sci. U.S.A., 108 (42), pp. 17378–17383, 2011, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Animal, Bacteremia, Bacterial Proteins, Cellular, Disease Models, Genes, Genetically Modified, Hemolymph, Host-Pathogen Interactions, Immunity, Insect, Mutation, Oral, Pseudomonas aeruginosa, Pseudomonas Infections, Quorum Sensing, Trans-Activators, Viral, Virulence

19.

Aoun, Richard Bou; Hetru, Charles; Troxler, Laurent; Doucet, Daniel; Ferrandon, Dominique; Matt, Nicolas

Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster Journal Article

J Innate Immun, 3 (1), pp. 52–64, 2011, ISSN: 1662-8128.

Abstract | Links | BibTeX | Tags: bioinformatic, DNA, Evolution, Gene Expression Regulation, Hemocytes, Immunity, In Situ Hybridization, Innate, Molecular, Mutation, Phylogeny, Sequence Analysis

2007

Journal Articles

18.

Beutler, Bruce; Eidenschenk, Celine ; Crozat, Karine ; Imler, Jean-Luc ; Takeuchi, Osamu ; Hoffmann, Jules A; Akira, Shizuo

Genetic analysis of resistance to viral infection Journal Article

Nature Reviews. Immunology, 7 (10), pp. 753–766, 2007, ISSN: 1474-1741.

Abstract | Links | BibTeX | Tags: Antiviral Agents, Disease Susceptibility, Drug Resistance, Eukaryotic Cells, Humans, Immunity, Mutation, Viral, Virus Diseases, Viruses

2006

Journal Articles

17.

Chen, Li-Ying; Wang, Juinn-Chin; Hyvert, Yann; Lin, Hui-Ping; Perrimon, Norbert; Imler, Jean-Luc; Hsu, Jui-Chou

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo Journal Article

Current biology: CB, 16 (12), pp. 1183–1193, 2006, ISSN: 0960-9822.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Antigens, Biological, Body Patterning, Cell Membrane, Differentiation, Dimerization, DNA-Binding Proteins, Embryo, Epistasis, Genetic, Immunity, Immunologic, Innate, Models, Mutation, Nonmammalian, Phenotype, Phosphoproteins, Receptors, Signal Transducing, Toll-Like Receptors, Transcription Factors, Zinc Fingers

16.

Galiana-Arnoux, Delphine; Dostert, Catherine ; Schneemann, Anette ; Hoffmann, Jules A; Imler, Jean-Luc

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila Journal Article

Nature Immunology, 7 (6), pp. 590–597, 2006, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Genetically Modified, Mutation, Nodaviridae, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Viruses, Viral, Viral Proteins, Virus Replication

15.

Leclerc, Vincent; Pelte, Nadège ; Chamy, Laure El ; Martinelli, Cosimo ; Ligoxygakis, Petros ; Hoffmann, Jules A; Reichhart, Jean-Marc

Prophenoloxidase activation is not required for survival to microbial infections in Drosophila Journal Article

EMBO Rep., 7 (2), pp. 231–235, 2006, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Bacterial Infections, Catechol Oxidase, Enzyme Activation, Enzyme Precursors, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Immunity, Innate, Mutation, Survival Rate

2004

Journal Articles

14.

Bischoff, Vincent; Vignal, Cécile; Boneca, Ivo G; Michel, Tatiana; Hoffmann, Jules A; Royet, Julien

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria Journal Article

Nat. Immunol., 5 (11), pp. 1175–1180, 2004, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Carrier Proteins, Cell Surface, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Mutation, Mycoses, Receptors, Staphylococcus aureus, Toll-Like Receptors

2003

Journal Articles

13.

Gobert, Vanessa; Gottar, Marie; Matskevich, Alexey A; Rutschmann, Sophie; Royet, Julien; Belvin, Marcia; Hoffmann, Jules A; Ferrandon, Dominique

Dual activation of the Drosophila toll pathway by two pattern recognition receptors Journal Article

Science, 302 (5653), pp. 2126–2130, 2003, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Carrier Proteins, Cell Surface, DNA Transposable Elements, Gene Expression, Genes, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Hypocreales, Insect, Insect Proteins, Mutation, Phenotype, Receptors, Serine Endopeptidases, Toll-Like Receptors

12.

Kurz, Léopold C; Chauvet, Sophie; Andrès, Emmanuel; Aurouze, Marianne; Vallet, Isabelle; Michel, Gérard P F; Uh, Mitch; Celli, Jean; Filloux, Alain; Bentzmann, Sophie De; Steinmetz, Ivo; Hoffmann, Jules A; Finlay, Brett B; Gorvel, Jean-Pierre; Ferrandon, Dominique; Ewbank, Jonathan J

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening Journal Article

Embo J, 22 , pp. 1451–60, 2003, ISBN: 0261-4189.

Abstract | Links | BibTeX | Tags: *Virulence, Animal, Caenorhabditis elegans/*microbiology, Mutation, Non-U.S. Gov't, Serratia marcescens/genetics/*pathogenicity, Support

2002

Journal Articles

11.

Ligoxygakis, Petros; Pelte, Nadège ; Hoffmann, Jules A; Reichhart, Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Journal Article

Science, 297 (5578), pp. 114–116, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, Hypocreales, Insect, Insect Proteins, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, Serine Endopeptidases, Tertiary, Toll-Like Receptors

10.

Gottar, Marie; Gobert, Vanessa; Michel, Tatiana; Belvin, Marcia; Duyk, Geoffrey; Hoffmann, Jules A; Ferrandon, Dominique; Royet, Julien

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein Journal Article

Nature, 416 , pp. 640–644, 2002, ISBN: 0028-0836.

Abstract | Links | BibTeX | Tags: Animal, Anti-Infective Agents/metabolism, Carrier Proteins/biosynthesis/genetics/*immunology, Drosophila melanogaster/genetics/*immunology/*microbiology, Drosophila Proteins/genetics/metabolism, Epistasis, Female, Genes, Genetic, Genetic Predisposition to Disease, Gram-Negative Bacteria/*immunology/physiology, Human, Insect/genetics, Messenger/genetics/metabolism, Mutation, Non-U.S. Gov't, P.H.S., Phenotype, RNA, Signal Transduction, Support, Survival Rate, Transgenes/genetics, U.S. Gov't

2001

Journal Articles

9.

Michel, T; Reichhart, Jean-Marc ; Hoffmann, Jules A; Royet, Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Journal Article

Nature, 414 (6865), pp. 756–759, 2001, ISSN: 0028-0836.

Abstract | Links | BibTeX | Tags: Amino Acid, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, Humans, Insect, Insect Proteins, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, Sequence Homology, Toll-Like Receptors

8.

Georgel, Philippe; Naitza, S; Kappler, Christine ; Ferrandon, Dominique ; Zachary, Daniel ; Swimmer, C; Kopczynski, C; Duyk, G; Reichhart, Jean-Marc ; Hoffmann, Jules A

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis Journal Article

Dev. Cell, 1 (4), pp. 503–514, 2001, ISSN: 1534-5807.

Abstract | BibTeX | Tags: Anti-Infective Agents, Apoptosis, Bacterial Infections, Caspases, Chromosome Mapping, Cysteine Proteinase Inhibitors, DNA Damage, Female, Gene Expression, I-kappa B Kinase, Immunocompromised Host, In Situ Nick-End Labeling, Insect Proteins, Male, Mutation, Phenotype, Protein Structure, Protein-Serine-Threonine Kinases, Tertiary

2000

Journal Articles

7.

Lagueux, Marie; Perrodou, E; Levashina, Elena A; Capovilla, Maria; Hoffmann, Jules A

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila Journal Article

Proc. Natl. Acad. Sci. U.S.A., 97 (21), pp. 11427–11432, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: alpha-Macroglobulins, Amino Acid, Cell Surface, Complement C3, Esters, Genetic, Insect Proteins, Janus Kinases, Membrane Glycoproteins, Mutation, Protein-Tyrosine Kinases, Proteins, Receptors, Sequence Homology, Sulfhydryl Compounds, Toll-Like Receptors, Transcription, Transcription Factors

6.

Imler, Jean-Luc; Tauszig, Servane ; Jouanguy, Emmanuelle ; Forestier, C; Hoffmann, Jules A

LPS-induced immune response in Drosophila Journal Article

Journal of Endotoxin Research, 6 (6), pp. 459–462, 2000, ISSN: 0968-0519.

Abstract | BibTeX | Tags: Biological, Cell Line, Cell Surface, Defensins, Genes, Genetic, Insect, Insect Proteins, Lipopolysaccharides, Membrane Glycoproteins, Models, Mutation, Promoter Regions, Receptors, Signal Transduction, Toll-Like Receptors

1999

Journal Articles

5.

Manfruelli, P; Reichhart, Jean-Marc ; Steward, R; Hoffmann, Jules A; Lemaitre, Bruno

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF Journal Article

EMBO J., 18 (12), pp. 3380–3391, 1999, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Cell Surface, Clone Cells, DNA-Binding Proteins, Fat Body, Female, Gene Expression Regulation, Genes, Insect, Insect Proteins, Larva, Male, Membrane Glycoproteins, Mosaicism, Mutation, Nuclear Proteins, Phosphoproteins, Receptors, Reporter, Signal Transduction, Toll-Like Receptors, Transcription Factors

1998

Journal Articles

4.

Levashina, Elena A; Ohresser, S; Lemaitre, Bruno; Imler, Jean-Luc

Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin Journal Article

Journal of Molecular Biology, 278 (3), pp. 515–527, 1998, ISSN: 0022-2836.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Antimicrobial Cationic Peptides, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Glycopeptides, Insect, Insect Proteins, Larva, Molecular, Mutation, Peptides, Promoter Regions, Recombinant Fusion Proteins, Reporter, Restriction Mapping, Transcription

1996

Journal Articles

3.

Lemaitre, Bruno; Nicolas, E; Michaut, Lydia ; Reichhart, Jean-Marc ; Hoffmann, Jules A

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults Journal Article

Cell, 86 (6), pp. 973–983, 1996, ISSN: 0092-8674.

Abstract | BibTeX | Tags: Antifungal Agents, Cell Surface, DNA-Binding Proteins, Fungi, Gene Expression, Genes, Insect, Insect Hormones, Insect Proteins, Membrane Glycoproteins, MHC Class II, Mutation, Mycoses, NF-kappa B, Phosphoproteins, Proteins, Receptors, Signal Transduction, Toll-Like Receptors

1995

Journal Articles

2.

Lemaitre, Bruno; Kromer-Metzger, E; Michaut, Lydia ; Nicolas, E; Meister, Marie ; Georgel, Philippe ; Reichhart, Jean-Marc ; Hoffmann, Jules A

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense Journal Article

Proc. Natl. Acad. Sci. U.S.A., 92 (21), pp. 9465–9469, 1995, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Bacterial Infections, Base Sequence, Gene Expression Regulation, Genes, Glycopeptides, Insect, Insect Hormones, Insect Proteins, Male, Mutation, Mycoses, Nucleic Acid, Peptides, Protein Binding, Recessive, Regulatory Sequences, Reporter, Survival Analysis

1.

Lemaitre, Bruno; Meister, Marie ; Govind, S; Georgel, Philippe ; Steward, R; Reichhart, Jean-Marc ; Hoffmann, Jules A

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila Journal Article

EMBO J., 14 (3), pp. 536–545, 1995, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Biological Transport, Cell Nucleus, Cell Surface, DNA-Binding Proteins, Fat Body, Gene Expression Regulation, Genetic, Immunity, Immunohistochemistry, Insect Hormones, Insect Proteins, Melanins, Membrane Glycoproteins, Mutation, Neoplasms, Nuclear Proteins, Phosphoproteins, Receptors, Signal Transduction, Toll-Like Receptors, Transcription, Transcription Factors