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2014

Journal Articles

31.

Majzoub, Karim; Hafirassou, Mohamed Lamine ; Meignin, Carine ; Goto, Akira ; Marzi, Stefano ; Fedorova, Antonina ; Verdier, Yann ; Vinh, Joëlle ; Hoffmann, Jules A; Martin, Franck ; Baumert, Thomas F; Schuster, Catherine ; Imler, Jean-Luc

RACK1 controls IRES-mediated translation of viruses Journal Article

Cell, 159 (5), pp. 1086–1095, 2014, ISSN: 1097-4172.

Abstract | Links | BibTeX | Tags: Cell Line, Cell Surface, Cytoplasmic and Nuclear, Dicistroviridae, GTP-Binding Proteins, Hepacivirus, Hepatocytes, Humans, Insect Viruses, Models, Molecular, Neoplasm Proteins, Peptide Initiation Factors, Protein Biosynthesis, Receptors, Regulatory Sequences, Ribonucleic Acid, Tumor, Virus Replication

30.

Imler, Jean-Luc

Overview of Drosophila immunity: a historical perspective Journal Article

Developmental and Comparative Immunology, 42 (1), pp. 3–15, 2014, ISSN: 1879-0089.

Abstract | Links | BibTeX | Tags: Allergy and Immunology, Animal, Antimicrobial Cationic Peptides, Antimicrobial peptides, History, Humans, IMD pathway, Immunity, Innate, innate immunity, Models, Pattern recognition receptors, Signal Transduction, Toll-Like Receptors

2013

Journal Articles

29.

Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng; Makino-Okamura, Chieko; Shilova, Victoria; Liu, Xi; Maksoud, Elie; Matsubayashi, Jun; Haddad, Iman; Spirohn, Kerstin; Ono, Kenichiro; Hetru, Charles; Rossier, Jean; Ideker, Trey; Boutros, Michael; Vinh, Joëlle; Hoffmann, Jules A

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge Journal Article

Proc. Natl. Acad. Sci. U.S.A., 110 (26), pp. 10717–10722, 2013, ISSN: 1091-6490.

Abstract | Links | BibTeX | Tags: Amino Acid, Chromatin Assembly and Disassembly, Escherichia coli, functional proteomics, Genes, Genetically Modified, Histone Acetyltransferases, Host-Pathogen Interactions, Humans, IMD interactome, Insect, Models, Molecular, Protein Interaction Maps, Sequence Homology, Signal Transduction, small ubiquitin-like modifier

2011

Journal Articles

28.

Imler, Jean-Luc; Ferrandon, Dominique

[Innate immunity crowned 2011 Nobel Prize winner] Journal Article

Med Sci (Paris), 27 , pp. 1019–24, 2011, ISSN: 0767-0974 (Print) 0767-0974 (Linking).

Links | BibTeX | Tags: *Immunity, *Nobel Prize, Biological, Genetic Association Studies, Humans, Immunotherapy/methods/trends, Innate/genetics, Models, Molecular Targeted Therapy/trends, Seasons, Structure-Activity Relationship, Toll-Like Receptors/chemistry/genetics/isolation & purification/physiology

27.

Ogawa, Michinaga; Yoshikawa, Yuko; Kobayashi, Taira; Mimuro, Hitomi; Fukumatsu, Makoto; Kiga, Kotaro; Piao, Zhenzi; Ashida, Hiroshi; Yoshida, Mitsutaka; Kakuta, Shigeru; Koyama, Tomohiro; Goto, Yoshiyuki; Nagatake, Takahiro; Nagai, Shinya; Kiyono, Hiroshi; Kawalec, Magdalena; Reichhart, Jean-Marc; Sasakawa, Chihiro

A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens Journal Article

Cell Host Microbe, 9 (5), pp. 376–389, 2011, ISSN: 1934-6069.

Abstract | Links | BibTeX | Tags: Autophagy, Biological, Cells, Cultured, Membrane Proteins, Mice, Microtubule-Associated Proteins, Models, Phagosomes, Protein Interaction Mapping, Shigella, Two-Hybrid System Techniques

26.

Lee, Kwang-Zin; Ferrandon, Dominique

Negative regulation of immune responses on the fly Journal Article

EMBO J., 30 (6), pp. 988–990, 2011, ISSN: 1460-2075.

Links | BibTeX | Tags: *Gene Expression Regulation, *Homeostasis, Bacteria, Bacteria/*immunology, Biological, Drosophila melanogaster/*immunology, Drosophila Proteins/biosynthesis/metabolism, Gene Expression Regulation, Homeostasis, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases/metabolism, Models, NF-kappa B, NF-kappa B/metabolism, ras Proteins, ras Proteins/metabolism, Receptor Protein-Tyrosine Kinases, Receptor Protein-Tyrosine Kinases/metabolism

2010

Journal Articles

25.

Silverman, Gary A; Whisstock, James C; Bottomley, Stephen P; Huntington, James A; Kaiserman, Dion; Luke, Cliff J; Pak, Stephen C; Reichhart, Jean-Marc; Bird, Phillip I

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems Journal Article

J. Biol. Chem., 285 (32), pp. 24299–24305, 2010, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: Biological, Caenorhabditis elegans, Cell Death, Cell Differentiation, Cell Survival, Homeostasis, Humans, Immunity, Innate, Mice, Models, Phenotype, Serpins, Transgenes, Transgenic

24.

Whisstock, James C; Silverman, Gary A; Bird, Phillip I; Bottomley, Stephen P; Kaiserman, Dion; Luke, Cliff J; Pak, Stephen C; Reichhart, Jean-Marc; Huntington, James A

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions Journal Article

J. Biol. Chem., 285 (32), pp. 24307–24312, 2010, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: Biological, Biological Transport, Biophysics, Catalytic Domain, Hormones, Humans, Kinetics, Models, Peptide Hydrolases, Protein Binding, Protein Conformation, Protein Structure, Serpins, Substrate Specificity, Tertiary, Thrombin

23.

Paquette, Nicholas; Broemer, Meike; Aggarwal, Kamna; Chen, Li; Husson, Marie; Ertürk-Hasdemir, Deniz; Reichhart, Jean-Marc; Meier, Pascal; Silverman, Neal

Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling Journal Article

Mol. Cell, 37 (2), pp. 172–182, 2010, ISSN: 1097-4164.

Abstract | Links | BibTeX | Tags: Alleles, Amino Acid Motifs, Biological, Caspases, Inhibitor of Apoptosis Proteins, MAP Kinase Kinase Kinases, Models, NF-kappa B, Sequence Alignment, Signal Transduction, Ubiquitin-Protein Ligases, Ubiquitination

2009

Journal Articles

22.

Fraiture, Malou; Baxter, Richard H G; Steinert, Stefanie; Chelliah, Yogarany; Frolet, Cécile; Quispe-Tintaya, Wilber; Hoffmann, Jules A; Blandin, Stéphanie A; Levashina, Elena A

Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium Journal Article

Cell Host Microbe, 5 (3), pp. 273–284, 2009, ISSN: 1934-6069.

Abstract | Links | BibTeX | Tags: Anopheles, APL1, Biological, Complement System Proteins, Hemolymph, Immunologic Factors, LRIM1, Models, Plasmodium, Protein Binding, Proteins, TEP1

21.

Cronin, Shane J F; Nehme, Nadine T; Limmer, Stefanie; Liegeois, Samuel; Pospisilik, Andrew J; Schramek, Daniel; Leibbrandt, Andreas; de Simoes, Ricardo Matos; Gruber, Susanne; Puc, Urszula; Ebersberger, Ingo; Zoranovic, Tamara; Neely, Gregory G; von Haeseler, Arndt; Ferrandon, Dominique; Penninger, Josef M

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection Journal Article

Science, 325 (5938), pp. 340–343, 2009, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: *Genome, *RNA Interference, Animal, Cell Proliferation, Drosophila melanogaster/*genetics/immunology/*microbiology, Drosophila Proteins/genetics/metabolism, Epithelial Cells, Epithelial Cells/cytology/physiology, Genetically Modified, Genome, Hemocytes, Hemocytes/immunology/metabolism/microbiology, Homeostasis, Immunity, Innate, Innate/*genetics, Insect, Intestinal Mucosa, Intestinal Mucosa/cytology/immunology/metabolism/microbiology, Janus Kinases, Janus Kinases/genetics/metabolism, Models, RNA Interference, Serratia Infections, Serratia Infections/genetics/*immunology/microbiology, Serratia marcescens, Serratia marcescens/*immunology/physiology, Signal Transduction, STAT Transcription Factors, STAT Transcription Factors/genetics/metabolism, Stem Cells, Stem Cells/cytology/physiology

2007

Journal Articles

20.

Ferrandon, Dominique

Ubiquitin-proteasome: pallbearer carries the deceased to the grave Journal Article

Immunity, 27 (4), pp. 541–544, 2007, ISSN: 1074-7613.

Abstract | Links | BibTeX | Tags: *Models, Apoptosis, Apoptosis/*physiology, Immunological, Macrophages, Macrophages/immunology/metabolism, Models, Phagocytosis, Phagocytosis/*physiology, Proteasome Endopeptidase Complex, Proteasome Endopeptidase Complex/*metabolism, Ubiquitin, Ubiquitin/*metabolism

19.

Ferrandon, Dominique; Gottar, Marie; Gobert, Vanessa

[New mechanism for detection of infections using the innate immune system of animals] Journal Article

Med Sci (Paris), 23 (8-9), pp. 707–709, 2007, ISSN: 0767-0974.

Links | BibTeX | Tags: Animal, Drosophila/immunology, Gram-Positive Bacteria, Gram-Positive Bacteria/pathogenicity, Gram-Positive Bacterial Infections, Gram-Positive Bacterial Infections/immunology, Humans, Immune System, Infection, Infection/*diagnosis/*immunology, Models

2006

Journal Articles

18.

Gottar, Marie; Gobert, Vanessa ; Matskevich, Alexey A; Reichhart, Jean-Marc ; Wang, Chengshu ; Butt, Tariq M; Belvin, Marcia ; Hoffmann, Jules A; Ferrandon, Dominique

Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors Journal Article

Cell, 127 (7), pp. 1425–1437, 2006, ISSN: 0092-8674.

Abstract | Links | BibTeX | Tags: Antibody Formation, Beauveria, Candida albicans, Carrier Proteins, Cellular, Glucans, Immunity, Immunological, Metarhizium, Models, Polysaccharides, Serine Endopeptidases, Signal Transduction, Virulence Factors

17.

Chen, Li-Ying; Wang, Juinn-Chin; Hyvert, Yann; Lin, Hui-Ping; Perrimon, Norbert; Imler, Jean-Luc; Hsu, Jui-Chou

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo Journal Article

Current biology: CB, 16 (12), pp. 1183–1193, 2006, ISSN: 0960-9822.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Antigens, Biological, Body Patterning, Cell Membrane, Differentiation, Dimerization, DNA-Binding Proteins, Embryo, Epistasis, Genetic, Immunity, Immunologic, Innate, Models, Mutation, Nonmammalian, Phenotype, Phosphoproteins, Receptors, Signal Transducing, Toll-Like Receptors, Transcription Factors, Zinc Fingers

2005

Journal Articles

16.

Martinelli, Cosimo; Reichhart, Jean-Marc

Evolution and integration of innate immune systems from fruit flies to man: lessons and questions Journal Article

J. Endotoxin Res., 11 (4), pp. 243–248, 2005, ISSN: 0968-0519.

Abstract | Links | BibTeX | Tags: Biological Evolution, Cell Surface, Forecasting, Humans, Immunity, Immunological, Innate, Membrane Glycoproteins, Models, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

2004

Journal Articles

15.

Leclerc, Vincent; Reichhart, Jean-Marc

The immune response of Drosophila melanogaster Journal Article

Immunol. Rev., 198 , pp. 59–71, 2004, ISSN: 0105-2896.

Abstract | BibTeX | Tags: Cell Surface, Immunity, Immunological, Innate, Models, Receptors, Signal Transduction, Toll-Like Receptors

14.

Ferrandon, Dominique; Imler, Jean-Luc; Hoffmann, Jules A

Sensing infection in Drosophila: Toll and beyond Journal Article

Semin Immunol, 16 , pp. 43–53, 2004, ISSN: 1044-5323.

Abstract | BibTeX | Tags: Carrier Proteins/chemistry/immunology/physiology, Cell Surface/immunology/*physiology, Drosophila Proteins/chemistry/immunology/*physiology, Drosophila/genetics/*immunology/microbiology, Fungi/immunology, Gene Expression Regulation, Gram-Negative Bacterial Infections/immunology, Gram-Positive Bacterial Infections/immunology, Immunological, Insect Proteins/chemistry/immunology/physiology, Models, Non-U.S. Gov't, Receptors, Signal Transduction/immunology/physiology, Support

13.

Blandin, Stephanie A; Shiao, Shin-Hong; Moita, Luis F; Janse, Chris J; Waters, Andrew P; Kafatos, Fotis C; Levashina, Elena A

Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae Journal Article

Cell, 116 (5), pp. 661–670, 2004, ISSN: 0092-8674.

Abstract | BibTeX | Tags: Anopheles, Female, Genetic, Humans, Insect Proteins, Insect Vectors, Malaria, Models, Molecular, Plasmodium berghei, Polymorphism, Protein Structure, RNA, Sequence Alignment, Tertiary

2003

Journal Articles

12.

Imler, Jean-Luc; Hoffmann, Jules A

Toll signaling: the TIReless quest for specificity Journal Article

Nature Immunology, 4 (2), pp. 105–106, 2003, ISSN: 1529-2908.

Links | BibTeX | Tags: Cell Surface, Dendritic Cells, Humans, Immunological, Interferon-beta, Membrane Glycoproteins, Mice, Models, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

11.

Luna, C; Hoa, N T; Zhang, J; Kanzok, S M; Brown, S E; Imler, Jean-Luc; Knudson, D L; Zheng, L

Characterization of three Toll-like genes from mosquito Aedes aegypti Journal Article

Insect Molecular Biology, 12 (1), pp. 67–74, 2003, ISSN: 0962-1075.

Abstract | BibTeX | Tags: Aedes, Base Sequence, Cell Surface, Chimera, Cloning, Developmental, Female, Gene Expression Regulation, Genetic, Insect Proteins, Male, Messenger, Models, Molecular, Mutagenesis, Promoter Regions, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sequence Alignment, Signal Transduction, Site-Directed, Transfection

2002

Journal Articles

10.

Hoffmann, Jules A; Reichhart, Jean-Marc

Drosophila innate immunity: an evolutionary perspective Journal Article

Nat. Immunol., 3 (2), pp. 121–126, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Biological Evolution, Cell Surface, Immunity, Immunological, Innate, Membrane Glycoproteins, Models, Receptors, Signal Transduction, Toll-Like Receptors

2000

Journal Articles

9.

Imler, Jean-Luc; Tauszig, Servane ; Jouanguy, Emmanuelle ; Forestier, C; Hoffmann, Jules A

LPS-induced immune response in Drosophila Journal Article

Journal of Endotoxin Research, 6 (6), pp. 459–462, 2000, ISSN: 0968-0519.

Abstract | BibTeX | Tags: Biological, Cell Line, Cell Surface, Defensins, Genes, Genetic, Insect, Insect Proteins, Lipopolysaccharides, Membrane Glycoproteins, Models, Mutation, Promoter Regions, Receptors, Signal Transduction, Toll-Like Receptors

1999

Journal Articles

8.

Hoffmann, Jules A; Kafatos, Fotis C; Janeway, Charles A; Ezekowitz, Alan R B

Phylogenetic perspectives in innate immunity Journal Article

Science, 284 (5418), pp. 1313–1318, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Active, Culicidae, Humans, Immunity, Immunological, Infection, Innate, Insect Vectors, Mammals, Models, Phagocytosis, Phylogeny, Proteins

1997

Journal Articles

7.

Meister, Marie; Lemaitre, Bruno; Hoffmann, Jules A

Antimicrobial peptide defense in Drosophila Journal Article

Bioessays, 19 (11), pp. 1019–1026, 1997, ISSN: 0265-9247.

Abstract | Links | BibTeX | Tags: Anti-Infective Agents, Gene Expression Regulation, Genetic, Insect Proteins, Models, Peptides, Promoter Regions, Signal Transduction

6.

Ferrandon, Dominique; Koch, I; Westhof, Eric; Nüsslein-Volhard, C

RNA-RNA interaction is required for the formation of specific bicoid mRNA 3' UTR-STAUFEN ribonucleoprotein particles Journal Article

EMBO J., 16 (7), pp. 1751–1758, 1997, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Base Sequence, Dimerization, DNA Primers, Embryo, Homeodomain Proteins, Insect Proteins, Messenger, Models, Nonmammalian, Nucleic Acid Conformation, Protein Biosynthesis, Ribonucleoproteins, RNA, RNA-Binding Proteins, Structural, Trans-Activators

1996

Journal Articles

5.

Hoffmann, Jules A; Reichhart, Jean-Marc ; Hetru, Charles

Innate immunity in higher insects Journal Article

Curr. Opin. Immunol., 8 (1), pp. 8–13, 1996, ISSN: 0952-7915.

Abstract | BibTeX | Tags: Base Sequence, Cyclic, Immunity, Immunologic, Immunological, Innate, Insects, Models, Peptide Hydrolases, Peptides, Receptors

1995

Journal Articles

4.

Cornet, B; Bonmatin, J M; Hetru, Charles; Hoffmann, Jules A; Ptak, M; Vovelle, F

Refined three-dimensional solution structure of insect defensin A Journal Article

Structure, 3 (5), pp. 435–448, 1995, ISSN: 0969-2126.

Abstract | BibTeX | Tags: Amino Acid, Bacteriolysis, Chemistry, Defensins, Diptera, Gram-Positive Bacteria, Hydrogen Bonding, Insect Hormones, Magnetic Resonance Spectroscopy, Models, Molecular, Physical, Physicochemical Phenomena, Protein Conformation, Recombinant Proteins, Sequence Homology, Solutions, Structure-Activity Relationship

1994

Journal Articles

3.

Meister, Marie; Braun, A; Kappler, Christine ; Reichhart, Jean-Marc ; Hoffmann, Jules A

Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter Journal Article

EMBO J., 13 (24), pp. 5958–5966, 1994, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Anti-Infective Agents, Base Sequence, beta-Galactosidase, DNA Mutational Analysis, Female, Gene Expression Regulation, Genetic, Genetically Modified, Germ Cells, Insect Hormones, Insect Proteins, Male, Models, Nucleic Acid, Promoter Regions, Recombinant Fusion Proteins, Repetitive Sequences, Transformation

1992

Journal Articles

2.

Bonmatin, J M; Bonnat, J L; Gallet, X; Vovelle, F; Ptak, M; Reichhart, Jean-Marc ; Hoffmann, Jules A; Keppi, E; Legrain, M; Achstetter, T

Two-dimensional 1H NMR study of recombinant insect defensin A in water: resonance assignments, secondary structure and global folding Journal Article

J. Biomol. NMR, 2 (3), pp. 235–256, 1992, ISSN: 0925-2738.

Abstract | BibTeX | Tags: Defensins, Hydrogen, Insect Hormones, Insects, Magnetic Resonance Spectroscopy, Models, Molecular, Protein Conformation, Recombinant Proteins, Saccharomyces cerevisiae, Thermodynamics

1988

Journal Articles

1.

Kappler, Christine; Kabbouh, M; Hetru, Charles; Durst, F; Hoffmann, Jules A

Characterization of three hydroxylases involved in the final steps of biosynthesis of the steroid hormone ecdysone in Locusta migratoria (Insecta, Orthoptera) Journal Article

J. Steroid Biochem., 31 (6), pp. 891–898, 1988, ISSN: 0022-4731.

Abstract | BibTeX | Tags: Biological, Ecdysone, Grasshoppers, Kinetics, Mixed Function Oxygenases, Models, NAD, NADP, Subcellular Fractions